What is the expression of cytokines?
Cytokine expression is a form of gene expression that regulates protein production called cytokines that send signals to the immune system. This expression involves "reading" of the genetic code of the cell and converting to proteins. Cells use the expression of cytokines to send certain instructions to immune tissues, for example to support inflammation near damage. Inappropriate expression can create an immune response against their own body and can cause diseases such as arthritis.
After injury, it enters the white blood cell area to uncover the residues and prevent infection. Damaged cells increase the expression of certain cytokines that attract these blood cells to the area. White blood cells initiate an inflammatory response, promote blood flow and the arrival of more white blood cells.
White blood cell inflammation also increases their own expression of cytokines. One important cytokine produced from gene expression is the factor of tumor necrosis (TNF) .TNF not only promotes inflammation but also helps destroy tumor cells and prevents replicasACI viruses. Its correct expression near the injury site is therefore a decisive means to prevent infection.
When the body was infected with foreign attackers, the expression of cytokines helps to regulate the immune response. Cells express and release certain cytokines that help immune cells know that they are part of the body and should not be attacked. Other cytokines are expressed after the cell infection and transmit this information to immune cells. These cells may then target an infected cell for destruction to spread the infection.
Sometimes pro -inflammatory cytokines are expressed incorrectly and can lead to autoimmune diseases. In rheumatoid arthritis, the continuing expression of cytokines near the synovial membranes, which forms the joints. Cytokines produced from this expression, such as TNF and interleukin-1 (IL-1), causing joint inflammation. TNF seems to be the main cytokin involved in arthritis andIts presence promotes the expression of other cytokines.
cytokine expression is not always a direct trigger for arthritis, but allows the disease to continue. It is believed that the initial small infection near the joint can lead to a disproportionate immune response. Immune cells can attack not only infection but also synovial membrane cells. Cytokines released by these immune cells promote continuing inflammation and damage to tissues.
osteoarthrosis is another disease that involves incorrect expression of cytokines. TNF and IL-1 cause bone tissue to degrade, promote inflammation and prevent the tissue itself. These cytokines also seem to prevent the expression of other factors that would support the healing or shutdown of the immune response. Therefore, some recent studies of osteoarthritis therapy are prosperized in preventing the expression of these cytokines.