What is hypersensitivity to drugs?

Drug hypersensitivity is an allergic syndrome that occurs after the drug is introduced into the body. The syndrome may start up to two months after exposure to the drug, but some patients are symptoms in one to three days. The body can respond in different degrees to the substance, which it considers foreign. The response shown in cases where the immune system is significantly involved can lead to death of organs or anaphylactic shock if it is not solved immediately. Common symptoms of syndrome are high fever, swollen lymph nodes and rash on the body. Almost 90 percent of cases are intolerance of the drug and are characterized by a patient who shows the expected toxic side effects at very low doses of the drug. Drug intolerance can be treated by interrupting the drug and treatment of any symptoms that persist after discontinuation. The drug intolerance mechanism is not clearly understandable, but it is sucking scientists are caused by the lack of enzyme, most likely partially genetic Pthe reason.

The most serious form of drug hypersensitivity is sometimes called serum disease and is mediated by an extensive immune response inside the body. This reaction represents 6 to 10 percent of drug hypersensitivity and some common associated medicines include penicillin, sulfa drugs and seizur drugs. When this type of hypersensitivity develops, the nature of symptoms depends on which part of the immune system fights against the substance. The most serious cases that can potentially lead to anaphylaxis and organ failure occur when the body produces an antibody IgE in response to the drug. IgE antibodies bind to mast cells and trigger the release of chemicals such as histamine that lead to a serious reaction.

drug hypersensitivity can occur at any time throughout the time of man. Although a person has not shown any signs of hypersensitivity during childhood or as a young adult, serious reactions may start laterEven in life. Sometimes repeated exposure potentially irritating drug causes the body to slowly form a dangerous allergy. The chances of developing serious hypersensitivity of the drug increase if the drug is used by injection rather than orally, and if the drug dose is large or often administered. Research strongly suggests that there is a genetic tendency to specific hypersensitivity to drugs and that people with the closest family who have known allergies