What is hippocampal sclerosis?
Hippocampal sclerosis is a disorder in which nerve cells die and the tissue of the scar is formed in the brain known as hippocampus. It is known that the condition is associated with approximately three quarters of cases of temporal lobe epilepsy, a disease in which people experience unusual feelings, along with changed emotions and behavior, muscle convulsions and sometimes convulsions. Despite this strong association, it is unknown whether hippocampal sclerosis causes epilepsy of temporary lobe or temporary lobe epilepsy causes hippocampal sclerosis. It is possible that both conditions are associated with other basic abnormality. Within the limbic system concerning the smell, the feeling of fear and creating long -term memory, Hippocampus participates in creating new memories. It is also the idea of playing a role in what is called spatial navigation, a process that depends on the fact that individuals can remember and compare their current and past positions in the environment to find each other. While sclerosis in this area of the brain isThe most commonly associated with the epilepsy of temporal lobe, often also participates in other structures in the limbic system, such as Amygdala, which controls a sense of fear.
by scanning magnetic resonance imaging (MRI), the main change observed in the hippocamp, when affected by hippocampal sclerosis, is a decrease in size. When viewing the hippocamp samples under the microscope, it is possible to see that individual nerve cells have been lost and scarring has been developed. This damage may be caused by an excessive amount of some neurotransmitters, chemicals that carry signals between the nerves that are released. These specific neurotransmitters bind to special receptors on nerve cells, causing calcium input; The excess of calcium overload leads to cellular death.
scientists have examined whether epileptic seizures can cause hippocampal sclerosis. It has been proposed that seizures that occur in childhoodOut, such as those associated with fever, could damage the brain, damage hippocampus and lead to epilepsy of temporal lobe in later life. While it has been found that some children who experience such seizures later have hippocampal sclerosis, most of them do not know whether sclerosis has developed before the first seizure. Another theory is that the defects in the time lobe can predict both for hippocampal sclerosis and seizures. Alternatively, the combination of hereditary, environmental and developmental factors could increase some people susceptible to epilepsy and sclerosis in the hippocamp.