What Is Liver Poisoning?

Diseases caused by chemical poisoning of the liver. According to the magnitude of hepatotoxicity to the liver, it can be divided into: highly toxic, phosphorus, trinitrotoluene, dinitrochlorobenzene, nitrobenzene, carbon tetrachloride, chloronaphthalene, acrolein, etc. Highly toxic, aniline, propane hydrazine, tetrachloroethane, dichloroethylene, methylene chloride, chloroform, arsenide, dimethylformamide, arsenic, antimony, mercury, selenium, etc. Low toxicity, dinitrophenol, toluene diamine, dichlorobenzene, chlorobenzene, chloromethane, DDT, 666, benzene, ethylene, ether, organic phosphorus, cyanide, acrylonitrile, lead, chromium, beryllium Wait. The pathological changes of acute toxic liver disease are hepatocyte necrosis and fat accumulation, and the clinical manifestations are similar to acute viral hepatitis. A few severe patients can develop acute yellow liver atrophy. The pathological changes of chronic toxic liver disease are fat accumulation and fibrosis. The clinical manifestations are similar to chronic viral hepatitis. Severe patients can develop cirrhosis. Except for disengagement and application of appropriate specific antidote, the treatment principle is similar to liver disease caused by other causes.

Toxic liver disease

Toxic liver disease

Diseases caused by chemical poisoning of the liver. According to the magnitude of hepatotoxicity to the liver, it can be divided into: highly toxic, phosphorus, trinitrotoluene, dinitrochlorobenzene, nitrobenzene, carbon tetrachloride, chloronaphthalene, acrolein, etc. Highly toxic, aniline, propane hydrazine, tetrachloroethane, dichloroethylene, methylene chloride, chloroform, arsenide, dimethylformamide, arsenic, antimony, mercury, selenium, etc. Low toxicity, dinitrophenol, toluene diamine, dichlorobenzene, chlorobenzene, chloromethane, DDT, 666, benzene, ethylene, ether, organic phosphorus, cyanide, acrylonitrile, lead, chromium, beryllium Wait. The pathological changes of acute toxic liver disease are hepatocyte necrosis and fat accumulation, and the clinical manifestations are similar to acute viral hepatitis. A few severe patients can develop acute yellow liver atrophy. The pathological changes of chronic toxic liver disease are fat accumulation and fibrosis. The clinical manifestations are similar to chronic viral hepatitis. Severe patients can develop cirrhosis. Except for disengagement and application of appropriate specific antidote, the treatment principle is similar to liver disease caused by other causes.

The manifestation of drug-induced liver injury in toxic liver disease

The clinical characteristics and severity of drug-induced liver injury can be quite different, usually divided into acute and chronic. Acute drug-induced liver injury includes acute hepatitis, intrahepatic cholestasis, acute fatty liver, and mixed types. The most common type of acute hepatitis is clinical diagnosis. On the one hand, the clinical manifestations caused by it are not much different from those of viral hepatitis, and fatigue, loss of appetite, and discomfort in the liver area can also occur; liver function abnormalities are also not special compared with patients with viral hepatitis. On the other hand, because of the high rate of hepatitis B surface antigen (HBsAg) in our population, these carriers are often diagnosed with hepatitis B when drug-induced liver injury occurs. Therefore, it is very easy for patients with liver injury to miss or misdiagnose if they ignore the history of liver injury drugs. ^[1]