What is oral biological availability?
oral biological availability must be understood in connection with the term biological availability. This applies to the amount of drugs that when entering the body, it actually gets into circulation. Different factors affect the amount or ratio of available drug. For example, when a drug is injected intravenously, the body is usually used because it goes directly to the bloodstream. This is not true when drugs are used by mouth and oral biological availability can be expressed as a ratio or percentage compared to the amount of chemical in the body when the drug is administered in intravenous form.
It is easy to understand that there are many things that can depart, or maybe increase the amount of available medicine that is swallowed. The digestive system or liver in the so -called first pass metabolism can absorb drugs in more or less. Depending on the degree of influence on medicines, it becomes more or less part of the bloodstream. Understanding the percentage of biological availability can then be usedTo determine the safe dosing, enough, but not too much, and it is comparable to intravenous use.
Each medicine must be considered highly individualized in terms of oral biological availability. Sometimes the way the drug is made and the form in which it is performed can slightly change the speed and degree of absorption. For example, it has been shown that certain brands are really better than generations because of the way they are made, even if they contain the same basic drugs. What distinguishes them is their formulation, other components and how their chemical structure reacts to the metabolism of the first passage.
There are a number of studies about how individual drugs are influenced by oral biological availability. To je také neuvěřitelně bohatá oblast výzkumu. When pharmacists and research design Medicines, they must constantly ask how the design affects absorption. Must also consider what situations couldcause certain drugs to degrade and whether the inactive ingredients or style of the drug (liquid, capsules, capsules, time release) would have any effect on the amount of medicine that hit the circulatory system.
Given the above facts, the only important matters are not the only important matters. Oral biological availability may change based on individual health and adding additional medicines or substances. Medicines to be taken with food may vary when taking without food. Adding antacids to many common medicines reduces oral biological availability and some fruit juices or citrus fruits can increase or reduce the percentage of drugs that reach the circulatory system. These changes may be scary because they could mean that a person is insufficiently treated or too medicated. Dosage must take into account personal habits, health and especially use other drugs, be it partition, prescription or herbal.
medicines that have about changes in use with other things, often toThey become warning labels that basically tell people that oral biological availability will change, and perhaps a dangerous way if the warning is not observed. Many times the changes are not extremely significant. However, any differences in absorption could prove problematic and could disrupt successful health treatment.