What Is Pick's Disease?

Pick's disease (Aronld-Pick's) is also known as lobular sclerosis; lobular atrophy; Alzheimer's disease; aphasia-loss of recognition-dyskinesia syndrome; Pick (A) syndrome. It is a rare disease.

Pick 's disease

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Pick's disease (Aronld-Pick's) also known as lobular sclerosis; lobular atrophy;

The disease occurs more than 40 to 60 years of age, the incidence rate is higher in women, slowly progressive dementia, and recent memory is gradually lost. Inarticulate, vague pronunciation, and disorganized speech. Personality and behavior changes, obvious obstacles to thinking, and more sleep. Occasionally hemiplegia, tremor, and convulsions. Hyperreflection or attenuation.

The EEG showed diffuse rhythm disturbances and high amplitude and slow activity. Brain CT showed symmetrical atrophy of the cerebral lobe, with obvious frontal and temporal lobes, and sometimes white matter demyelination.

(1) Simple senile dementia: Onset after 70 years of age, memory disorders often appear first (forget about recent events, and then loss of distant memory), fictional and destructive disorders, misunderstanding . Visible speech disorders, incorrect use of vocabulary, and structural apraxia, but no signs of other speech disorders. With the exception of hypertonic muscles in the limbs and mild or unstable strong grip reflexes, there are also few positive signs of neurological examination.

(2) Alzheimer-senile dementia (Alzheimer-senile dementia) In addition to the above-mentioned symptoms of simple senile dementia, an increasingly obvious aphasia-apraxia-failure syndrome; often accompanied by prefrontal symptoms such as lips Reflexes (caused by sight and touch at some basic azimuth points); significant resistance to hypertonia, stereotyped movements, eye movement disorders; Balint-like syndromes and repetition of speech. Epilepsy and seizures can also occur.

(C) Pick's disease This disease has a slow onset, and some trauma is often considered to be the cause of the disease. This disease is almost indistinguishable from Alzheimer's disease clinically. It is dominated by localized atrophy of the brain, and the degree of atrophy on both sides is often asymmetric. Localized atrophy is most common. Occasionally, the ventricles are enlarged. There were no senile plaques and neurofibrillary tangles and Pick inclusions under the microscope.