What is the dopamine hypothesis of schizophrenia?
Dopamine hypothesis schizophrenia is the theory of how people develop this mental illness. Dopamine is an important neurotransmitter in the brain that alleviates basic behavior such as motivation. This hypothesis claims that overproduction or excessive dopamine release is part of what causes schizophrenia. The evidence of the imaging of the brain and the pharmacology supporting the hypothesis includes observing that drugs that cause psychosis also cause increased activity in the nerve pathways that depend on dopamine. Scientists disagree with whether the dopamine hypothesis is the correct schizophrenia.
Dopamine is the main catecholamine neurotransmitter in mammals, including humans, and is essential for nerve pathways that control voluntary movement and alleviate many behavioral systems. Schizophrenia is a mental illness characterized by symptoms such as hallucinations and paranoia, which often makes its patients who are unable to function in everyday life. It can sometimes be treated with psychiatric drugs, from nMany of them block specific neurotransmitter effects and change brain chemistry. Dopamine hypothesis schizophrenia is a medical theory that claims that this mental illness results from a disorder of neurons that produce dopamine or rely on it in their normal physiology.
Dopamine hypothesis schizophrenia is partly originating in observations of ways of drugs used to treat mental diseases. Some drugs bind to dopamine receptors on different neurons, activate them, while other drugs bind to the same receptors, but prevent them from activating. Medicines such as cocaine and many other psychoactive substances cause dopamine production that correlates with the increase in symptoms that resemble schizophrenia such as hallucinations and paranoia. Functional brain imaging and some pathological tests indicate that the production and circulation of premises during the manifestations of schizophrenic symptoms also in P P.Acients.
dopamine is particularly important for the four main paths of interconnected neurons in the brain, including mesocortical and mesolimbic pathways that are associated with searching for reward and motivated behavior. In the hypothesis of dopamine schizophrenia, the lack of normal organization and motivation is attributed to the mesocortical pathway disorder, it may spread to closely related mesolimbic rewards that alleviate normal motivation and addictive behavior. While schizophrenia has genetic factors and environmental factors, fans of dopamine hypothesis point to a relatively high predominance of catecholamin in abnormal schizophrenic brain systems.
Critics of hypothesis dopamine schizophrenia notice that drugs that block dopamine receptors do not always reduce schizophrenic symptoms. Many psychoactive or psychicotropic drugs successfully used to treat schizophrenia are substituted femethylamins, a chemical group that affects receptors for many chemicals in the brain, not onlydopamin. Neuroanatomic studies of schizophrenic brains reveal significant changes in coarse shape and structure of certain regions that may indicate a different origin for this disease than changes in dopamine pathways. There is no scientific consensus on the role of dopamine.