What Is the Dopamine Hypothesis of Schizophrenia?
The dopamine hypothesis is one of the important hypotheses of the biochemical pathological hypothesis of schizophrenia. Regarding the causes of schizophrenia, the dopamine hypothesis believes that schizophrenia is caused by a disorder in the metabolic process of the brain, which leads to the imbalance of certain chemicals in the brain-mainly the accumulation of excess neurotransmitters or excessive consumption. [1]
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- Chinese name
- Dopamine hypothesis
- Foreign name
- Dopamine hypothesis
- The dopamine hypothesis is one of the important hypotheses of the biochemical pathological hypothesis of schizophrenia. Regarding the causes of schizophrenia, the dopamine hypothesis believes that schizophrenia is caused by a disorder in the metabolic process of the brain, which leads to the imbalance of certain chemicals in the brain-mainly the accumulation of excess neurotransmitters or excessive consumption. [1]
- The dopamine hypothesis believes that imbalance in dopamine levels and dysregulation of dopamine receptor activity in the brain of patients with schizophrenia are one of the causes of schizophrenia. The hypothesis is mainly based on some phenomena found during the application of antipsychotic drugs in schizophrenia. Antipsychotic drugs such as phenothiazines and butyryls have pharmacological effects associated with dopamine receptor blockade. And high-value antipsychotic drugs are powerful dopamine receptor blockers. Patients who take large amounts of amphetamine for a long time have symptoms similar to paranoid schizophrenia. The pharmacological effect of amphetamine is mainly to increase dopamine release, thereby enhancing dopamine receptor-mediated signaling and leading to hyperfunction. Therefore, it is speculated that hyperfunction of dopamine is at least related to paranoid schizophrenia. [2]