What Is Vaginal Intraepithelial Neoplasia?

Vaginal intraepithelial neoplasia (VAIN) may be a precancerous lesion of vaginal epithelial cancer. About 5% of VAIN (with or without treatment) eventually develops into invasive cancer. More common in women over 60 years of age, the average age of VAIN III patients is 53 years. Most patients with VAIN have suffered from cervical intraepithelial neoplasia (CIN); 1% to 3% of VAIN coexist with CIN. It is suggested that VAIN may be extended from CIN, or it may be a satellite lesion. ^[1]

Vaginal intraepithelial neoplasia

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Vaginal intraepithelial neoplasia (VAIN) may be a precancerous lesion of vaginal epithelial cancer. About 5% of VAIN (with or without treatment) eventually develops into

The cause is unclear. Vaginal epithelium with

Vaginal intraepithelial neoplasias often become asymptomatic. Sometimes because

The diagnosis is based on pathological examination.

VAIN treatment emphasizes individualization. The condition of the lesion (range, location, grade, number), the condition of the patient (age, fertility requirements, etc.), and the treatment method (effect, function / structural impact) should be considered comprehensively.

VAIN: The lesions are often multiple, with active

VAIN recurrence rate is 10% -42%. Over time, the relapse rate increases. Multiple lesions, 5-FU treatment alone, HPV infection, and immunosuppression are all risk factors for VAIN recurrence. Persistent VAIN may develop into invasive cancer. Therefore, any VAIN patient requires long-term follow-up. Generally, vaginal cytology smears should be performed at 3, 6, and 12 months after treatment, if necessary, colposcopy, and at least once a year thereafter. ^[1]