What are different types of COX inhibitors?

Cyclooxygenase inhibitors (COX) are medicines that prevent pain and swelling by interference either COX-2 or Cox-1 and 2 together. In this way, many different drugs work. They are all in the class of drugs known as non -steroidal anti -inflammatory drugs (NSAIDs). Aspirin, acetaminophene and celecoxib are common types of COX inhibitors.

In 2011, there are no medicines on the market that only inhibit COX-1, but are available medicines that block Cox-1 and Cox-2 enzymes. These drugs work by preventing the release of chemicals that cause swelling and pain. COX-1 blocking can damage the stomach protective layer, which may lead to irritation or serious stomach lining problems, so these drugs are usually used only in small doses or for a short period of time.

Some of the common COX inhibitors that block Cox-1 and Cox-2 are aspirin, ibuprofen and acetaminophen. Everyone reduces pain and swelling of steroids. Although they can be used to treat specific conditions, they are more commonly used forGeneral pain relief, such as injury, headache or arthritis. These drugs can also thinner blood, a factor in their interference with COX-1 and can reduce the risk of heart attack or stroke.

Valdecoxib, Rofecoxib and Cecoxib are three types of COX inhibitors that affect only COX-2. In 2011, only cecoxib is still available in the United States, although Rofecoxib can be purchased in other parts of the world. Rofecoxib and Valdecoxib have been withdrawn from the market because both increase the risk of heart attack or stroke.

Celecoxib is the only type of COX-2 inhibitor that has been used since 2011. It is used to treat pain and inflammation, especially if they are caused by menstrual convulsions or arthritis. When used to treat varost arthritis types, the wholecoxib does not stop the disease progression, but can be safely used for long -term relief from symptoms. Abdominal side effects arecommon with the use of this drug, although it causes less irritation and inflammation in the stomach lining than COX inhibitors that block the production of Cox-1 and Cox-2. The risk of a patient of the cerebral stroke or infarction increases when the use of cecoxib, but this risk may be considered acceptable in some cases.