What is the use of pemeterrexed and cisplatins?
In 2008, the United States approved food and drug management a combination of Poestrexed and cisplatins as treatment of non-flu, non-small cell lungs. While Pemerexed and Cisplatin were used individually for years before chemotherapeutic substances, cisplatin was previously used mainly in the treatment of advanced bladder cancer and metastizing gonadal tumors. Like other compound drugs containing platinum, cisplatin could still be used in the treatment of a variety of other cancers. However, the Pemetrexed, although always prescribed, besides another chemotherapeutic agent, was always considered to be specific to the malignant pleural mesothelioma and other non -mass cell cancer. During the Phase III clinical study, it was better to find that the combination of permeter and cisplatin was caused by less hematological toxicity than the combination of gemcitabin HC1 and cisplatins in patients with non -partial histology of histology cells. Even ifThis may prove to be a significant development in cancer research, these two drugs bring a considerable risk.
The side effects of Pemerorexed and cisplatins may be relatively serious, including vomiting, constipation, pharyngitis, stomatitis, anemia, reducing immunity and reducing the number of red and white blood cells. These side effects may occur in up to one of the five patients using a combined drug. Other common side effects include dizziness and confusion, weakness and fatigue, change of mood and depression, or even joint and muscle pain.
The risks of treatment of Pemetrexed and Cisplatins are not negligible. It is important that patients are monitored for itching, rash or stressed breathing, all signs of potentially fatal anaphylactic reactions to drugs. Some patients develop tinnitus - ringtone and other sounds in the ears, loss of high -frequency hearing, reduced hearing sharpness or even hlUchota as a result of ototoxicity cisplatin. The risk of hearing loss is considerably higher in young children receiving the drug. In addition, due to hematological toxicity of combined drugs, some patients may require blood transfusions due to treatment.
risks such as dangerous drug interactions can be easily managed. While a comprehensive list of interactions with Pemeterrexed and cisplatin drugs is relatively long and includes a diverse pharmaceutical class, only a few are commonly used drugs. Drug medicines in non -steroidal anti -inflammatory class (NSAIDs) drugs may dramatically disrupt clotting in patients undergoing chemotherapy. This includes common painkillers such as ibuprofen and naproxen. For this reason, it is important to consult a doctor closely consult with a doctor before using any medicine, while undeléching Pemerexed and cisplatin.