What causes cancer resistance?
Chemotherapy drugs focus on the specific properties of cancer cells, which are abnormal cells whose genetic material has mutated. The mutation rate is so high that each tumor is made up of cells with different mutations. This can allow the cell and its products to change the appearance. Anti -tumor drugs may not recognize target cells or tumor can actively block the medicine from work. Mutations and their results are therefore very important for research on drug resistance in cancer.
Drug resistance in cancer develops when the tumor contains both sensitive and resistant cells. The drug kills sensitive cells but leaves resistant. Initially, the drug may reduce the tumor and it seems that treatment works.
As the characteristics of cancer cells, it is that they proliferate uncontrollably, cancer residues can begin to grow again. Therefore, chemotherapy commonly uses more than one medicine. Different drug events can focus on cell with different mutations.
Every time the cell is reproduced, the genetic mat canThe edition inside the cell to suffer from a mutation, a change in a genetic sequence. Genes cells are the plan of the structure and products of this cell. Mutations may be beneficial, neutral or harmful to the cell. Favorable mutations sometimes allow cells to survive the attack, resulting in cancer resistance.
occasionally cancer cells may contain an abnormal amount of chromosomes. People usually have 46 chromosomes, half of which are duplicates another 23. Drug resistance in cancer is more likely if the tumor contains cells with less or more than 46 chromosomes.
anti -cancer drugs may have to be entered into the cell to perform a therapeutic effect. The external structural components of the cell can be changed by genetic mutation. These components can be reduced ltrubated or the number of drugs for drugs.
In the case of a estrogen receptor in breast or ovarian cancer may be the target componentcompletely lost. In these cases, the drug cannot reach through the membrane in adequate quantities or not at all. Tumor cells can also be able to send the drug back from the cell after it gets in. Cancer cell may also have an increased ability to break the medicine once in.
Another drug can work by linking to a particular molecule and blocking its function. If the target is mutated for the target, the appearance of the molecule may change sufficiently to prevent the drug detection. The cell can also produce an increased concentration of the target molecule, which allows some to escape the drug. This may happen if the cell genome contains more copies of the relevant gene than usual or if the cell can stimulate the gene to produce much more molecules than usual.