What Is a Therapeutic Vaccine?

Therapeutic vaccine refers to natural, artificially synthesized or expressed products using genetic recombination technology in the body that has been infected with pathogenic microorganisms or has suffered from certain diseases by inducing specific immune responses to achieve treatment or prevention of disease progression . Before 1995, the medical community generally believed that vaccines were only used for disease prevention. With the development of immunological research, new uses of vaccines have been discovered, which can treat some refractory diseases. Since then, vaccines have both preventive and therapeutic effects, and therapeutic vaccines are specific active immunotherapy.

Therapeutic vaccine

Therapeutic vaccine refers to the induction of pathogenic microorganisms or organisms

In 1998, the antiviral effect of hepatitis B virus therapeutic vaccine was studied by using HBV gene transfer mice as an animal model abroad. In the same year, in France and Japan, a therapeutic vaccine formulated with polypeptides expressed by certain gene fragments of hepatitis B virus and various adjuvants was also used for clinical research.

Therapeutic vaccine book information

Title: Therapeutic

vaccine

Author: Wen Yumei

Publisher: Science Press

Publication time: September 1, 2010

ISBN: 9787030285454

Folio: 16

Price: 98.00 RMB

Introduction to therapeutic vaccines

As a new type of therapeutic vaccine, a large amount of experience has been accumulated at home and abroad in basic and clinical research, applied foundation, preclinical and clinical research theory and technology. "Therapeutic Vaccine" comprehensively introduces the action mechanism and application of therapeutic vaccine, which is divided into two parts: the general part explains the overall theory and technology, including vaccines and their types, persistent infections, History, theory and experimental basis, animal experiments, chapters on therapeutic vaccines based on antigen-antibody complex types, DNA, peptides, dendritic cells, and clinical research and validation of therapeutic vaccines; monographs introduce some treatments Vaccines for specific diseases include hepatitis B, hepatitis C, AIDS, human papilloma virus, tuberculosis, chronic bacterial infections, and cancer therapeutic vaccines.

"Therapeutic Vaccine" is suitable for reference for researchers, teaching staff and graduate students engaged in vaccine research and development.

Therapeutic Vaccine Book Catalog

The first summary

Chapter 1. Vaccines and their types

Section 1 Development of Vaccines

Section 2 Types of Vaccines

Chapter 2 Persistent Infection

Classification of persistent infections

Section 2 Diseases of Persistent Infection in Humans

Model of persistent infection

Section 4 Mechanisms that constitute persistent infections

Chapter III History of Therapeutic Vaccines

The first prodromal period (1850 ~ 1885)

Section 2 Start-up Period (1890-1911)

Section III Development Period (1912 ~ 1947)

Section 4 Slow Period (1950 ~ 1993)

Section V Revival Period (1993-present)

Chapter 4 Basic Theories and Basic Knowledge of Therapeutic Vaccines

Classification of therapeutic vaccines

The basic theory of pathogens and their components as therapeutic vaccines

Section 3 Basic Theory of Regulating Innate Immunotherapy Vaccines

Section 4 Basic theories of targeted specific immunotherapeutic vaccines

Section 5 Preclinical Experimental Research and Clinical Research

Chapter V Animal Models and Experiments of Therapeutic Vaccines

Duck hepatitis B virus

Section 2 Marmot Animal Model

Section 3 Transgenic Mouse Model of Hepatitis B Virus

Section 4 Other Animal Models

Chapter 6 Antigen-Antibody Complex Therapeutic Vaccine

Antigen-antibody reaction

Biological function of antigen-antibody complex

Section III Antigen-antibody immunogenic complex (IC) and therapeutic vaccine

Chapter VII DNA therapeutic vaccine

Section 1 DNA vaccine overview

Strategies for improving and enhancing DNA vaccines

Application of therapeutic DNA vaccines

Section 4 Industrialization of DNA Therapeutic Vaccine

Chapter VIII Polypeptide therapeutic vaccine

The first section of the concept of peptide therapeutic vaccine

Section 2 Strategies for the development of peptide therapeutic vaccines

Section 3 Research Technology of Peptide Therapeutic Vaccine

Section 4 Research Progress of Peptide Therapeutic Vaccine

Problems and prospects in the development of peptide vaccines

Chapter IX Dendritic Cell Therapy Vaccine

Section I Overview

Biological characteristics of DC

Section 3 Conditions and Methods of DC Loading Antigen

Section 4 Classification of DC vaccines targeting antigen loading

Section 5 Preparation of DC Vaccine

Section 6 DC Vaccine Treatment Design and Related Issues

Section VII Clinical Trials of DC Vaccine and Evaluation

Section VIII Existing Problems and Application Prospects

Chapter 10 Clinical Studies of Therapeutic Vaccines

The first section of domestic and foreign progress in clinical research of therapeutic vaccines

Section 2 Advances in clinical efficacy and safety of therapeutic vaccines

Section III proposes experimental research in clinical studies of therapeutic vaccines

Chapter 11 Clinical Verification of the Efficacy of Complex Therapeutic Vaccines

The first stage of clinical research

Design of clinical trials

Section III Quality Assurance and Quality Control of Clinical Trials

Section 4 Particularity of Verification of Therapeutic Vaccine

The second monograph

Chapter 12 Hepatitis B Therapeutic Vaccine

Section I Basic and Biological Characteristics of Hepatitis B Virus

Section 2 Mechanism of persistent infection caused by hepatitis B virus

Section III Development of Hepatitis B Therapeutic Vaccine

Section 4 Compound Therapeutic Hepatitis B Vaccine (Bg)

Opportunities and Challenges of Hepatitis B Therapeutic Vaccines

Chapter 13 Clinical Study of Compound Hepatitis B Therapeutic Vaccine

The first section of clinical trials

Section II Phase IIa Clinical Trials

Section III Phase IIb Clinical Trials

Questions about Section IV Therapeutic Vaccine

Chapter 14 Therapeutic Hepatitis C Vaccine

Section 1 Basic Biological Characteristics of Hepatitis C Virus

Section II Immunological Mechanism of Hepatitis C Virus Persistent Infection

Section III Development of Hepatitis C Prevention and Therapeutic Vaccine

Chapter XV AIDS therapeutic vaccine

The first section is the need to develop a therapeutic vaccine for AIDS

Section 2 Possibility of developing AIDS therapeutic vaccine

Section III Major Advances in AIDS Therapeutic Vaccines

Section 4 Problems and Prospects for AIDS Therapeutic Vaccine Research

Chapter 16 Therapeutic vaccine against human papilloma virus

Section 1 HPV Biological and Molecular Biological Characteristics

Section II Immune Response to HPV Infection

Section III HPV therapeutic vaccine

Chapter 17 Tuberculosis therapeutic vaccine

Section 1 Characteristics of TB infection

Section 2 studies the urgency of TB therapeutic vaccines

Section 3 History of TB Vaccine Research

Section 4 Reasons for Poor BCG Immunity

Section 5 Immune Mechanism of TB Vaccine

Research Status of TB Therapeutic Vaccine

Section VII Development Trends of TB Therapeutic Vaccine

Chapter 18. Therapeutic vaccine for chronic bacterial infections

Section 1 Characteristics of Bacterial Infection and Antibacterial and Immune Mechanism

Research on bacterial therapeutic vaccines

Chapter XIX Therapeutic Vaccine

The first section of the concept of tumor vaccine

Tumor immune escape mechanism

Section 3 Basic Strategies for Cancer Vaccines

Section 4 Types of Cancer Vaccines

Section 5 Development Trend of Cancer Vaccine

Chapter 20 Development Prospects for Therapeutic Vaccines

The first section is rooted in deep multidisciplinary basic theories

Section 2 Establishing a standardized evaluation system step by step

Section III Gradually Widening the Field

Section 4 Close ties with clinical and manufacturing companies

Section 5 Establishing Bases and Training Talents