What is Baclofen?
Baclofen is a muscle relaxant and anti-spasmodic drugs approved by US food and drug management (FDA) in November 1977. It is mainly used to treat muscle spasticity in patients suffering from musculoskeletal conditions such as brain envelope and multiple sclerosis. The spasticity of muscle concerns elevated muscle tone, involuntary convulsions and rigidity often caused by the central nervous system disorders. Alcohol -dependent alcohol cure is believed to be alcohol -dependent.
Baclofen is a similar neurotransmitter gamma-aminobutyreic acid (GABA), a chemical that naturally occurs in the body and allows information to go through the nerves. Baclofen is believed to inhibit inappropriate information and reactions transmitted between the nerves in the part of the brain that controls skeletal muscles. By inhibiting these responses, the drug allows the drug to relax and reduce convulsions, even if no positive effects have been found when the medicine is used to treat rheumatic disorders. 84 Participants of Study suffering CirhoThe liver and alcohol addiction was randomly assigned either by placebo or Baklofen. The treatment was administered three times a day and the baclofen dose was increased from 5 mg daily to 10 mg daily after a week. The attempt lasted 12 weeks.
In a 12 -week experiment, abstinence was considered less than 14 drinks a week and less than four drinks a day. The results showed that alcohol abstinence was achieved and maintained for a significantly higher percentage of patients who received baclofen compared to those who received placebo. The average diameter of the cumulative alcohol abstinence achieved in patients who were administered by Baklofen was 62.8 days; The average average for those who got placebo was 30.8 days.
The study has shown that the level of alcohol abstinence achieved when using baclofen was significant enough to reduce further liver damage. Baclofen, unlike many drugs that help alcohol with abstinence, has Mal's liver's liverEffect, because it passes through the body mainly unchanged, with the metabolism of the liver only 15 percent. This means that patients who are already suffering from a diseased liver would be able to take Baklofen without increasing the liver damage, although other studies are necessary to determine the long -term effects of baclofen in patients with alcohol dependence.
Baclofen should only be accepted on the advice of the healthcare professional and the dosage should never change without the advice of the doctor. If Baklofen has been used for a long time, sudden withdrawal can lead to hallucinations and seizures. Due to the low level of liver metabolism, Baklofen is excreted by the kidneys primarily unchanged. This means the renal function of May to be adversely affected, especially if it is collected for a long time.