What is cisplatin nephrotoxicity?
cisplatin nephrotoxicity concerns kidney damage, the main side effect of this drug for cancer, especially at high doses. Scientists are not sure why cisplatin accumulates in the kidneys at higher levels than in other organs. Preventive measures such as extra hydration and forced urination can help reduce the side effects of nephrotoxicity cisplatins. Sulfa drugs administered with cisplatin can also block the toxic effects of the kidney drug.
kidney damage can affect up to one third of all patients undergoing cisplatin to stop the growth of the tumor. The risk of nephrotoxicity cisplatin increases with higher doses of this platinum compound. During chemotherapy treatment, metal is absorbed by human tissue before urine is excreted, usually within a few days, from the liver, lungs, testicles and other organs. The drug responds differently on the kidneys, with higher drug levels remaining after infusion. This reaction may be particularly important in the treatment of older patients and patients with guyHami kidneys. Scientists
have found that increasing the amount of fluids before, during and after intravenous chemical infusion could reverse the cisplatin nephrotoxicity. The cisplatin is administered only intravenously, without the use of oral form of the drug. Cancer specialists usually add salt solution and at the same time infusion of drugs and recommend to patients to drink up to 3 liters (about 2.8 liters) of fluid a day to rinse metals from the kidneys.
Diuretics can also be used to enforce urination and clean the medicine from the kidneys along with drugs on sulfa. For example, sulf drugs administered to patients with ovarian cancer can effectively allow high doses of chemotherapy without kidney damage. Other detoxifying agents can also help.
Scientists have discovered strong anticancer properties of platinum -based drugs at the beginning of the 70th. The years of the treatment of tumors in the lungs, bladder, breast, uterus, head and neck. Scientists have found that high doses of treatmentIva needed to kill cancer cells also caused nephrotoxicity of cisplatin. They believe that the drug changes DNA in certain cells found in the kidneys.
In addition to this side effect, magnesium levels could be dangerously low after chemotherapy with drugs with drugs. Magnesium is decisive for the proper functioning of the central nervous system, heart and muscles. Supplements can reverse these shortcomings.
The most common determination of side effects will end within a few weeks after the end of treatment. They include vomiting and nausea that could be controlled by drugs against nausea. There may also be anemia or a low number of white blood cells that represent a common side effect of many chemotherapeutic drugs. These chemicals usually kill healthy cells along with malignant cells that could prevent the body's immune system to combat infection.