What Is DPP 4?

DPP-4, also known as T cell surface antigen CD26, also known as ADABP, ADCP2, DPPIV, TP103, dipeptidyl peptidase 4, dipeptidyl peptidase IV, T cell activation antigen CD26, adenosine deaminase Complex protein 2, a serine protease on the cell surface. ^[1]

DPP4

DPP-4 is highly expressed in the intestine, and is also expressed in the liver, pancreas, placenta, thymus, etc., and is partially present in circulating blood in a soluble form. Soluble DPP-4 has enzymatic activity, and its main role is to preferentially cut and remove the first two amino acids at the amino terminus of the oligopeptide whose second amino acid at the amino terminus is alanine (Ala) or proline (Pro).

DPP4 is an enzyme in the body, which is an enzyme. Its main role is to break down proteins in the body. One of the proteins degraded by DPP4 is called GLP-1, which is a hormone secreted by intestinal cells. GLP-1 can be reduced by stimulating insulin, inhibiting glucagon, inhibiting gastric emptying, and regenerating islet cells. blood sugar. DPP4 inhibitors that cause DPP4 inactivation and do not decompose GLP-1 have become one of the main directions for the treatment of diabetes.

DPP4 inhibitors that are currently the most in-depth research and have been used clinically include Sitagliptin, Vildagliptin, Saxagliptin, Alogliptin, and Liglitin (Linagliptin).