What Is Drug Metabolism?
Drug metabolism refers to the process of changing the chemical structure of drugs under the action of a variety of drug metabolizing enzymes in the body (especially liver drug enzymes), also known as biotransformation or drug metabolism. The biological transformation and excretion of drugs is called elimination. There are two kinds of results after the biotransformation of drugs in the body: one is inactivation, which becomes a non-pharmacologically active drug; the other is activation, which changes from non-pharmacologically active to a pharmacologically active metabolite or produces a toxic metabolite, or remains after metabolism The original pharmacological effect, so biological transformation can not be called the detoxification process. [1]
Drug Metabolism
- Drug metabolism refers to the process of changing the chemical structure of drugs under the action of a variety of drug metabolizing enzymes in the body (especially liver drug enzymes), also known as biotransformation or drug metabolism. The biological transformation and excretion of drugs is called elimination. There are two kinds of results after the biotransformation of drugs in the body: one is inactivation, which becomes a non-pharmacologically active drug; the other is activation, which changes from non-pharmacologically active to a pharmacologically active metabolite or produces a toxic metabolite, or remains after metabolism The original pharmacological effect, so biological transformation can not be called the detoxification process. [1]
- Drug absorption and interaction
- There are two main ways of elimination of drugs from the body, namely metabolism and
- Drug Metabolism
- 1. Effect of administration route and dosage on metabolism;
- 2. Enzymatic and enzymatic effects;
- 3 Physiological factors affecting drug metabolism: sex; age; individual; disease; diet.