What is involved in aspirin metabolism?

Aspirin metabolism differs somewhat in individuals due to one or more factors that can delay absorption or reduce efficiency. Aspirin is made of acetylsalicylic acid (ASA) and a small number of esters and ethers, which are secondary metabolites that help in tissue absorption and body organs. The effectiveness of aspirin varies according to the dosage and general health and medical history of the patient. For example, high cholesterol in older patients somewhat reduces aspirin efficiency.

In order to be most effective, aspirin should be the stomach content between an acidity of 2.15 and 4.10. After oral use of aspirin, it begins to dissolve when it enters into the stomach liquids. The half -life cycle of aspirin metabolism begins in the stomach approximately 10 minutes after ingestion. 25 minutes, blood aspirin levels in the bloodstream will fall to 50% of the level it reaches when the metabolism begins. In these 15 minutes aspirin Will will pass into the small intestine for accelerated absorption and distribution of blood in the tissue and organs of the body to start her PRthe Žáci.

At the end of its time in the stomach, ASA transforms into salicylic acid due to the interaction between the mucous membrane of the stomach and the enzyme called aspirin esterase (AE). Some studies have found that the activity of AE esterase is performed higher than normal glucose and fatty acids in the bloodstream during aspirin metabolism. Aspirin metabolism in the small intestine accelerates to distribute it to organs and tissues throughout the body; However, the liver seems to be a primary focus for further metabolization. Up to 80% of aspirin metabolism takes place in the liver where it undergoes rapid chemical changes in combination with liver acids and hepatocytes. Aspirin begins to interfere with the prostaglandin's whole body to reduce the sensitivity to pain and reduce the sticky of platelets that could lead to clots.

Once the metabolism of aspirin is completed, the distribution of salicylic acid moves behindBlood plasma on fluids throughout the body. Some travel to mix with synovial fluids that cartilage and joint cushions on the joints. In joints, aspirin focuses on prostaglandins to reduce inflammation and pain. This can also be found in saliva and backbone fluids, as well as in the main organs of the kidneys, lungs and hearts. As Aspirin easily exceeds placental barriers and can be found in breast milk, pregnant and breastfed women should ask a healthcare professional before accepting aspirin.

Aspirin takes up to 48 hours to completely exclude from the kidney body. The excretion rate varies greatly due to the changing pH levels throughout the body. Health conditions such as diabetes, stomach ulcers and high levels of cholesterolus aspirin effective or delay in people of all age groups. Older people, especially fragile and those who had previous hearts, will also see a wide variability of metabolic speeds, efficiency and speed of excretion.