What is Lincomycin?

Lincomycin is one of lincosamide antibiotics used to treat bacterial infections. It was developed from the biological product of the ACTINOMYTES called Streptomyces Lincolnensis. With chemical modification of thionyl chloride, Lincomycin becomes clindamycin. The mechanism of action and bacterial coverage of this drug is similar to the mechanism of macrolides, which means that it inhibits the synthesis of protein by binding 50 Shedberg (50s) ribosomal subunit and is active against many gram-positive cocci and bacilli and some gram-negative cocci. It is no longer used as a first -line treatment due to the risk of side effects and the availability of safer drugs. Perfringens and Clostridium tetani. It works against some types of mycoplasms, Actinomycetes and Plasmodium. Lincomycin is not effective against many Enterococcus faecalis strains. It is also inactive against hemophilus influenzae, neisseria gonorrhoeae, neisseria meningitidis and other gram -negative bacteria and yeast. Many safer medicines are now available,that provide coverage of the above organisms, so the use of lincomycin is reserved for serious infections that are resistant to other drugs or for people who have serious antibiotic allergies to penicillin.

Lincomycin is effective against serious anaerobic infections and can be administered orally, intramuscularly, intravenously, locally or subconjunctively. The oral form is best taken on an empty stomach one to two hours before meals, because the food reduces the speed and range of absorption. However, it causes gastrointestinal symptoms such as nausea, vomiting and diarrhea. Some people experience headache, dizziness, convulsions and painful mouth. These symptoms are expected to disappear when the body adapts to lincomycin, but the persistent and increasing severity of the symptoms should cause a doctor to consult.

All forms of lincomycin can cause reactions such as urticaria, dermatitis, multifOrme erythema and itching of the anal area. The feared side effects on this medicine include non -compromise of white blood cells known as agranulocytosis, aplastic anemia and a generalized decrease in the number of all blood cells known as pantrytopenia. Anaphylaxis, hypotension and pseudomembranous colitis are also very serious side effects that ensure the interruption of the drug use.

people with liver or kidney disease should take preventive measures when using this drug. The explanation of this is that bile and urine are an important means of secreting this drug. In renal or liver damage, this medicine remains in the blood longer and can cause toxicity. Unfortunate, when this drug is overdose, hemodialysis or peritoneal dialysis cannot be effectively removed from the blood. Doctors usually reduce the dose by up to 25 to 30% in people with liver or kidney disease to prevent toxicity.