What Is Self-Healing?

Regeneration is the whole body or organ being traumatized by external force and partially lost. On the basis of the remaining part, a structure that is the same in shape and function as the lost part is grown. This repair process is called regeneration.

regeneration

(Vocabulary of pathology)

Regeneration (regeneration):

1. Full regeneration: refers to the regeneration of cells to completely restore the original tissue and cell structure and function.

2. Incomplete regeneration: regeneration that occurs via fibrous tissue, also known as

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1. Regeneration of epithelial tissue:

Covered epithelium regeneration: In squamous epithelial defects, the basal layer cells divide and proliferate from the wound margin or bottom, and migrate to the defect center, forming a single layer of epithelium, and then proliferating and differentiate into squamous epithelium.

Glandular epithelium regeneration: Its regeneration varies according to the state of injury. Glandular epithelium defect The glandular basement membrane is not damaged and can be supplemented by the remaining cell division to completely restore the original glandular structure; it is difficult to regenerate when the glandular structure (including the basement membrane) is completely destroyed.

2. Regeneration of fibrous tissue: Fibroblasts in the damaged area divide and proliferate under stimulation.

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Cell death and cell damage caused by various factors can stimulate cell proliferation. As a key part of regeneration, cell proliferation is largely regulated by the extracellular microenvironment and various chemical factors. Excessive stimulatory or inhibitory factors can lead to cell proliferation and uncontrolled growth of tumors. Cell growth can be accomplished by shortening the cell cycle, but the most important factor is getting the resting cells back into the cell cycle.

The role of extracellular matrix in cell regeneration

The extracellular matrix (ECM) occupies a considerable proportion in any tissue. Its main function is to connect cells together to support and maintain the physiological structure and function of the tissue, thereby affecting the regeneration of cells. Both cells and stable cells have full regenerative capabilities, but whether they can be reconstituted into normal structures still depends on ECM, because the latter plays a more active and complex role in regulating the biological behavior of cells. It can affect cell morphology, differentiation, migration, proliferation, and biological functions. The information provided can regulate embryonic development, tissue reconstruction and repair, wound healing, fibrosis, and tumor invasion. Therefore, the extracellular matrix plays an important role in the cell regeneration process.