What is the relationship between aspirin and inflammation?

Inflammation is a natural reaction of the body caused by injury. Drugs classified as non -steroidal anti -inflammatory drugs (NSAIDs), such as aspirin, generally all work to reduce this reaction in a similar way. The relationship between aspirin and inflammation is caused by the unique effects of this drug to the cellular level. NSAIDs, such as ibuprofen and acetaminophen, have similar interactions at this level, but do not occur to the same extent as aspirin.

One ingredient involved in the inflammatory response is the enzyme cyclooxygenase-1 (COX-1), a protein that helps to activate other compounds known as prostaglandins. Prostaglandins usually stimulate the cells of the immune system to release compounds that cause inflammation. This medicine works on inhibition of coox enzymes, so the relationship between aspirin and inflammation depends on this action.

Most NSAID reversibly suppress the EX-1 enzyme, but aspirin irreversibly prevents it, which makes dynamicuaspirin and inflammation somewhat unique. A group of atoms called the acetyl group,It is added to the COX enzyme with aspirin. Such an increase prevents the COX-1 enzyme in relation to prostaglandins, prevents any activation and forcing the body to create more COX-1 enzymes before inflammation.

The relationship between aspirin and inflammation also directly includes other proteins involved in the causes of this phenomenon. One type of protein, known as the nuclear factor Kappa B (NF-KB), helps as one of these causes to enter cells. Once inside the cell, the NF-KB goes to the nucleus, where genetic information is stored and stimulates the cell to switch inflammatory chemicals.

Aspirin has been shown to have actions that also affect NF-KB. In this interaction between aspirin proteins and inflammation, this medicine preferences other protein, Kappa B (IKB) inhibitor, from breaking. IKB usually helps to restore NF-KB off the cells and keep it inactive. During an inflammatory reaction IKB would destroy other proteins called kinases,But aspirin acts to stop this process. In this way, IKB remains outside the cells and is able to continue its effects of maintaining an inactive NF-KB. The latter protein is therefore unable to influence the genetic information of cells and these cells are refrained by the formation of inflammatory proteins.

Due to its wide range of effects, aspirin is able to prevent inflammation at several levels. This versatility is useful in the treatment of different types of inflammation with different causes. Aspirin has other types of interactions with cells and proteins that allow this drug to reduce fever and perception of pain that are independent of these effects.

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