What is the blood -brain barrier?

Blood barrier-BBB is a protective barrier that is designed to keep the environment in the brain as stable as possible. It prevents many dangerous substances to enter the brain and protect the brain from a range of potential risks, from infection to elevated hormone levels in the body. Of course, the barrier from the bleed-franka also prevents some useful things, so the administration of some drugs to treat the brain and the central nerve conditions somewhat demanding.

In a sense, the blood barrier is as a protective ditch with a drawbridge. It is located in capillaries that lead to the brain. The walls of the capillaries are usually highly permeable, allowing you to go through different blood -soluble ingredients in water and into the body. In the brain, capillary walls are very compact and dense, allowing several substances to the brain.

This means that when they are toxins and infectious materials around the blood, they cannot reach the brain. It is very good news for the brain because the brain is a very fragile organ and damage to infections byIt could have been devastating. However, some harmful substances may still go through: for example, viruses can pass through the blood barrier-cut. Substances can also go through a bloody threshing barrier when the brain host body is experiencing a head trauma in the form of invasive surgery or a serious decline.

The discovery of a barrier from a bleed is usually credited to Edwin Goldmann, a researcher in 1913, who tried to understand why the brain could not change color when the dye was injected into the bloodstream. He grabbed the idea of ​​injection of the dye directly into the brain and realized that the dye could not expand, suggesting that it is maintained by a barrier. With the development of advanced medical imagianges in the 1960s, scientists learned much more about how the blood -brain barrier worked.

This protective barrier goes in both ways: harmful material can't get into the brain but also can't get enoughAt out if she manages to get into her brain. This makes it difficult to treat brain infections, as the infection may be captured in the brain and the drugs used to treat such infections elsewhere in the body may not be able to cross the blood -brain barrier. This requires formulation of drugs that can exceed this barrier or delivery of drugs directly to the brain.