What is the renin-English system?
The renin-English system (RAS) is a hormonal system in the human body, which is mainly known for the regulation of blood pressure (BP) and fluid volume. It is named for its two central agents, Renin and angiotensin. The renin-English system is also known as the Renin-Angiotensin-Aldosterone (RAAS) system as a result of the third main participant of this system called Aldosteron. The level of renin-English system activity determines and is determined by the BP level. Low BP is clinically known as hypotension. The kidney through its secretory cells containing granules called juxtaglomerular cells releases Renin. This type of enzyme is also released when the sympathetic nervous system is low blood volume, activity in the sympathetic nervous system, or when the cells macula denssa juxtaglomerular apparatus detect a reduction in sodium chloride levels.
Renin separates the session, which is a release from the liver called angiotensinogen. This cleavage process converts angiotensinogen into angiotensin I. This substanceAnd it is classified as a decapeptide, which means it consists of a ten amino acid chain. Angiotensinogen is also known for its role in this process as a precursor of angiotensin.
Angiotensin and in itself are inactive. This changes when it reacts with another enzyme, which is produced from the vascular endothelium of the lungs, a thin layer of flat cells that line the organ capillaries. It is known as the enzyme converting angiotensin (ACE) and is responsible for converting angiotensin to angiotensin II, an active form of this particular peptide. This does by taking off two of your terminal remnants.
As an active angiotensin II peptide, it limits blood vessels, a process known as vasoconstriction. Thus, narrowed passages lead to limited FLA blood as a result of the increase in BP, clinically as hypertension. In addition, angiotensin II activates the release of hormonal aldosterone from the kidney juxtaglometer cells. AldoSteron causes reabsorption of water and sodium in the kidneys, leading to an increase in blood volume and in the extension of BP.
The pharmaceutical industry responded by introducing three drug classes. Have been created to alleviate or regulate the Renin-English system. Renin or blockers inhibitors are designed to suppress Renin from the transformation of angiotensinogen to angiotensin I. ACE inhibitors are designed for the next step, inhibiting angiotensin to angiotensin II. Finally, there are angiotensin II receptor Angagonists - they also know angiotensin receptor blockers (ARB) - who block the activation of angiotensin II.