What is Renin's journey?
Renin path is a human biological system that controls certain aspects of circulation such as blood pressure. This path includes a cascade of reactions that are initiated by the kidneys in response to low blood pressure. Also known as the Renin-Angiotensin-Aldosterone (RAS) system, the Renin road can be manipulated by drugs to reduce blood pressure in some people with hypertension.
This journey begins in the kidneys in response to low renal blood flow, a sign of low blood pressure. When the low flow of renal blood is detected, the kidneys create an enzyme called renin and secrete it into the bloodstream. In Renin's blood, it reacts with a protein called angiotensinogen to form angiotensin I. an enzyme called angiotensin converting enzyme (ACE) converts some of the angiotensin I to angiotensin II. Both new proteins are vasoconstrictors that cause blood vessels to reduce and increase blood pressure in the kidneys.
The primary -intention of the Renin Track is controlled by blood pressure is to regulate the blood volume. VolumeIn the body, it is influenced by the amount of sodium and water that is used and excreted. The excretion of sodium and water is regulated by the kidneys that release more of these substances into the urine when larger quantities are used.
Together with the regulation of blood volume, the Renin track has another important function: control of systemic vascular resistance. This is a measure of the amount of blood resistance to the blood flow of the arteries and blood vessels in the body. Systemic vascular resistance is influenced by a number of things, including renin activity and factors such as blocking artery and blood vessels. For example, if the artery is partially blocked by plaques deposits, greater pressure to push blood through the system is required.
Blood volume and systemic vascular resistance check heart dispensing and arterial pressure. Cardiac output is a measurement based on the amount of blood released by the heart when it beats, and how many times the heart beats per minute. Arterial pressure is a pressure generated by noErpating blood from the left ventricle of the heart. Together all these factors regulate blood pressure.
Finally, the Renin track controls blood pressure directly by regulating blood volume and systemic vascular resistance, which in turn affects heart expenditure and arterial pressure. These effects are initiated by the kidneys and mediated by ACE. This means that medicines that prevent ACE effects can help some people with high blood pressure, and in fact it is the basis of the class of hypertensive medicines called ACE inhibitors. These drugs help reduce blood pressure by preventing ACE in the conversion of angiotensin and angiotensin II.