What Is a Microsatellite?

In the late 1980s, James of the Marshfield Medical Research Foundation and Wis of Oregon Health Sciences University isolated a type of satellite DNA with shorter repeat units than small satellite DNA. , Called microsatellite DNA, also known as Short Tandem Repeats (STRs) or Simple Sequence Repeats (SSRs). Distribution, microsatellite DNA sequences are divided into 3 types: pure, compound, and interrupted

Microsatellite

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In the late 1980s, James of the Marshfield Medical Research Foundation and Wis et al. Of Oregon Health Sciences University separated a comparison

A simple repeat in the genome, for example:

Single type: ATATATATATATATATATATATAT

Composite: ATATATCACACACACACACAC

Intermittent: ATATATCA ATATATCA ATATATA

Microsatellite DNA conforms to the Mendelian genetic model, co-dominantly expressed, and is widely distributed in the genome of eukaryotes, including coding and non-coding regions. Studies have shown that it may be "strand slippage" during DNA replication This phenomenon results in higher polymorphic information content (PIC) of microsatellite DNA.

Motif in a microsatellite. For example, in the ATATATATATATATATATATATAT sequence, AT is the repeating unit of the sequence. In the division of repeating units, it is generally considered that:

CA = AC = GT = TG

AGC = GCA = CAG = GCT = CTG = TGC

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