What Is the TATA Box?

The TATA box (TATA box / Hogness box) is one of the elements constituting the promoter of eukaryotes. The consensus sequence is TATAATAAT (non-template chain sequence). It is about -30bp (-25 ~ -32bp) upstream of the transcription start point of most eukaryotes. It is basically composed of AT base pairs. It is the choice that determines the start of gene transcription and is one of the binding sites of RNA polymerase Only after the RNA polymerase is firmly bound to the TATA box can transcription begin. Deletion of mutagenesis causes changes in the transcription site, so its function is to ensure the correct localization of transcription. In the initial process of mRNA precursor transcription, the transcription factor TF2 and the TATA box are combined to form a stable complex, and then other transcription factors and RNA polymerase are combined with DNA in a certain temporal and spatial order to form a transcription initiation complex. Start transcription.

TATA box

discuss

The TATA box (TATA box / Hogness box) is one of the elements constituting the promoter of eukaryotes. The consensus sequence is TATAATAAT (non-template chain sequence). It is about -30bp (-25 ~ -32bp) upstream of the transcription start point of most eukaryotes. It is basically composed of AT base pairs. It is the choice that determines the start of gene transcription and is one of the binding sites of RNA polymerase. Only after the RNA polymerase is firmly bound to the TATA box can transcription begin. Deletion of mutagenesis causes changes in the transcription site, so its function is to ensure the correct localization of transcription. In the initial process of mRNA precursor transcription, the transcription factor TF2 and the TATA box are combined to form a stable complex, and then other transcription factors and RNA polymerase are combined with DNA in a certain temporal and spatial order to form a transcription initiation complex Start transcription.

Chinese name

TATA box

Foreign name

TATA box / Hogness box

Nature

One of the elements that make up a eukaryotic promoter

Consistent order

TATAATAAT (non-template chain sequence)

details

Among the genes of eukaryotes, Hogness et al. First found in the globin gene the Hogness region similar to the pribrow region of the prokaryote, that is, the TATA box (Goldberg-Hogness box or Hogness box), which is located upstream of the transcription start point -25 ~ Common sequence at -30 bp. In addition, another common sequence CCAAT was bred at -70 -78 bp upstream of the start site, which corresponds to the -35bp region (Sextama region) in prokaryotes. It is called the CAAT box.