What Are the Signs of an Allergic Reaction to Histamine?

Histamine is produced by histidine under the action of decarboxylase. Mast cells in many tissues, especially the skin, lungs, and intestinal mucosa, contain large amounts of histamine. Histamine is released when tissue is damaged or when inflammation and allergic reactions occur. Histamine has a strong vasomotor effect, and can increase the permeability of the walls of capillaries and venules. Plasma leaks into the tissue, causing local tissue edema. ^[1]

Basic Information

Chinese name: histamine
Foreign name: Histamine
Nature: Autoactive substance
Synthesize: Decarboxylated from histidine in the body

Chemical formula: C5H9N3
Molecular weight: 111
Poisoning: Flushing dizziness headache nausea arrhythmia
Detection method: ELISA method

Histamine indication

1. It is mainly used for the examination of gastric secretion function to identify whether there is true gastric acid deficiency in patients with gastric cancer and malignant anemia. At present, pentapeptide is used as a substitute for gastric acid-stimulating hormone, and this product has been used less frequently.

2. Aided diagnosis of leprosy.

3. It is also used in clinical desensitization, that is, repeated incremental injections of small doses of histamine can improve the tolerance of patients to histamine. This method is used clinically to treat patients with unexplained allergies after specific examination. Certain treatment effect.

Clinical application of histamine

1. Prepare various injections containing 1.0 × 10mg, 1.0 × 10mg, 1.0 × 10mg, 1.0 × 10mg, 1.0 × 10mg of this product per ml, starting from the injection of 1.0 × 10mg of this product per ml. Subcutaneous injection, 0.5 ~ 1ml each time, and then increase the concentration 10 times daily, you can achieve the purpose of desensitization.

2. Dilute the 1mg / ml injection solution 10 times to 0.1mg / ml, first take 0.1ml subcutaneously and then increase it by 0.1ml daily until 1ml, which can also desensitize.