What Is Chronic Toxicity?
Chronic toxicity refers to the toxicity caused by long-term low-dose effects of chemicals on organisms, and the duration of exposure is 1-2 years. Determination of chronic toxicity teratogenicity, mutagenicity, carcinogenicity. [1]
- Chronic toxicity refers to the toxicity caused by long-term low-dose effects of chemicals on organisms, and the duration of exposure is 1-2 years. Determination of chronic toxicity teratogenicity, mutagenicity, carcinogenicity. [1]
Definition of chronic toxicity
- Chronic toxicity refers to the toxicity caused by long-term low-dose effects of chemicals on organisms, and the duration of exposure is 1-2 years. Determination of chronic toxicity teratogenicity, mutagenicity, carcinogenicity. [1]
- chronic toxicity
- Damage to function or structure caused by long-term exposure to poison or poisoning.
- Chronic toxicity is an important indicator for measuring accumulated toxicity, and it is also important information for formulating health standards.
- It usually involves the toxic effect dose, the nature of the action, the target organ, the degree of damage (reversible or irreversible lesions), and the harmless effect dose.
- It is the main basis for predicting that humans may cause chronic harm through excessive exposure to harmful substances in the living environment and production environment.
Chronic toxicity assessment principles
- The evaluation is based on the maximum non-action dose obtained from the chronic toxicity test. The principles are: (1) The maximum non-action dose is 50 times the possible human intake, indicating that the toxicity is strong, and the test substance should be abandoned for food. (2) When the human ingestion is 50 times <the maximum non-action dose <100 times the human's possible intake, after safety evaluation. Only then can the test substance be used for food. (3) When the maximum non-acting dose is 100 times the possible human intake, consideration may be given to allow application to food. [2]