What is Clomipramine?

Clomipramine tablets are sugar-coated tablets, which are white or slightly yellow after removing the sugar coating.

Clomipramine tablets

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Clomipramine tablets are sugar-coated tablets, which are white or slightly yellow after removing the sugar coating.

Drug Name

Clomipramine tablets

Whether prescription drugs

Non-prescription drugs

Athletes use with caution

Inadvertent use

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Drug Information

Clomipramine hydrochloride pinyin name: YansuanLumipamingPian
English name: ClomipramineHydrochlorideTablets
Page number: 2000 edition two-679
Source (Molecular Formula) and Standard This product contains mipamin hydrochloride (C19H23ClN2.HCl) should be 90.0% to 110.0% of the labeled amount.
[Character] This product is a sugar-coated tablet, which is white or slightly yellow after removing the sugar coating.
[Identification] (1) Take an appropriate amount of fine powder of this product and follow the identification (1), (2), (4) tests under clomipramine hydrochloride to show the same response.
(2) Take the solution under the content measurement and determine it by spectrophotometry (Appendix IVA). It has the maximum absorption at the wavelength of 252nm and a shoulder at the wavelength of 270-280nm.
[Inspection] Take 1 tablet of this product, put it into a 50ml measuring bottle, and add about 40ml of 0.1mol / L hydrochloric acid solution.
Shake for 1 hour, dilute to the mark with 0.1mol / L hydrochloric acid solution, shake well, filter, and measure the content according to the method from "Precise amount of the filtrate to the appropriate amount" according to the method under content determination, and the content should meet the requirements (Appendix XE ).
Others should comply with the relevant provisions under the tablet (Appendix IA).
[Content determination] Take 20 tablets of this product, add a small amount of 0.1mol / L hydrochloric acid solution and grind it. Use 0.1mol / L hydrochloric acid solution to transfer to a 250ml measuring flask, shake thoroughly to dissolve clomipramine hydrochloride, add 0.1 Dilute the mol / L hydrochloric acid solution to the mark, shake well, and filter. Precisely take the appropriate amount of the filtrate. Quantitatively dilute with 0.1mol / L hydrochloric acid solution to make a solution containing about 20g per 1ml, and shake well. According to the spectrophotometric method (Appendix IVA), the absorbance was measured at a wavelength of 252 nm, and calculated according to the absorption coefficient (E1% 1cm) of C19H23ClN2.HCl as 226.
[Category] Same as clomipramine hydrochloride.
[Specifications] (1) 10mg (2) 25mg
[Storage] shading and sealed.
The main ingredient of this product is clomipramine hydrochloride,
Its chemical name is: N, N-dimethyl-10,11-dihydro-3-chloro-5H-dibenzo [b, f] azepine-5-propylamine hydrochloride.
Molecular formula: C19N23ClN2 · HCl
Molecular weight: 351.32
[Pharmacology and toxicology] This product is a tricyclic antidepressant. Its main function is to block the reuptake of norepinephrine and serotonin in the central nervous system. It has a stronger blocking effect on the reuptake of serotonin, and It exerts antidepressant and anxiolytic effects, as well as sedative and anticholinergic effects.
[Pharmacokinetics] Oral absorption is fast and complete, bioavailability is 30 ~ 40%, protein binding rate is 96 ~ 97%, half-life (t1 / 2) is 22 ~ 84 hours, apparent volume of distribution (Vd) is 7 ~ 20L / kg, metabolized in the liver, the active metabolite is norclomipramine, excreted by the urine. This product can be secreted into milk.
[Indications] Used to treat various depression states. It is also commonly used in the treatment of obsessive-compulsive neurosis and phobic neurosis.
[Usage and dosage] Oral treatment of depression and obsessive-compulsive neurosis, the initial dose is 25mg once, 2-3 times a day, slowly increase to the treatment volume of 150 ~ 250mg a day within 1 to 2 weeks, and the high dose does not exceed 300mg a day . For the treatment of phobic neurosis, the dosage is 75 ~ 150mg a day, and it is taken orally in 2 ~ 3 times.
[Adverse reactions] Anticholinergic reactions may occur at the beginning of treatment, such as sweating, dry mouth, blurred vision, difficulty urinating, and constipation. Central nervous system adverse reactions can appear lethargy, tremor, dizziness. Orthostatic hypotension can occur. Occasionally seizures, abnormal ECG, bone marrow suppression or toxic liver damage.
[Contraindications] Patients with severe heart disease, recent history of myocardial infarction, epilepsy, glaucoma, urinary retention, and allergies to tricyclic drugs.
[Precautions] Use with caution in patients with severe liver and kidney dysfunction, prostatic hypertrophy, elderly or cardiovascular disease. ECG should be monitored during use. This product should not be used in combination with a monoamine oxidase inhibitor. It should be used 14 days after the monoamine oxidase inhibitor is stopped. Patients should discontinue treatment immediately when they have a tendency to turn to mania. It is not advisable to drive vehicles, operate machinery or work at height during medication.
[Medication for pregnant and lactating women] Use with caution in pregnant women. Breastfeeding women should stop breastfeeding while using this product.
[Children's medication] Disabled for children under 6 years old, and reduced for children over 6 years old as appropriate.
[Medication for elderly patients] Start with a small dose, slowly increase the dose, and reduce the dose as appropriate.