What is megaloblastic anemia?
Blood deficiency involving the production of large erytroblasts in the bloodstream is called megaloblastic anemia. Megaloblastic anemia, which comes from a basic deficiency, can also indicate anemia with a lack of folate or malignant anemia depending on the cause of the lack of symptoms and increase the risk of an individual for the development of serious complications. Treatment of megaloblastic anemia usually involves determining the source of deficiency and administration of supplements to compensate for the existing deficit. When there is a lack of, it adversely affects the formation of red blood cells, leading to the development of excessive, abnormally shaped erytroblasts known as megaloblasts. As a result of their slowed development, megaloblasts do not like fast enough to compensate for their reduced numbers. The fragile structure of the megaloblast is susceptible to rupture and eventually leaves an individual with insufficient red blood cells.
individuals with megaloblastic anemia generally suffer from vitamin B12 deficiency or folic acid. With malignant anemia, there is insufficient protein production in the stomach known as an internal factor. The lack of internal factor inhibits the stomach ability to absorb vitamin B12, which worsens the production of red blood cells. As a result, megaloblast production increases, leading to the development of malignant anemia. Research has found that lack of folic acid or folate also contributes to the development of megaloblasts because its presence is necessary to support the proper formation and maturation of red blood cells.
Secondary or basic conditions and environmental factors also have Been is known to contribute to the development of folate deficiency anemia. Individuals with leukemia or bone disorders such as myelofibrosis may develop megaloblastic anemia. Regular use of certain drugs such as barbiturates, phenytoin and alcohol may also contribute to the development of this form of anemia. This typeAnemia can also develop individuals who consume a diet that does not have essential vitamins, nutrients and minerals or those who had parts of their small intestine or stomach. Digestive problems arising from disorders such as celiake or Crohn's disease or recent infection may support the onset of megaloblastic anemia.
individuals with this form of anemia can experience a number of symptoms that may include persistent fatigue, pale or yellowish skin and frequent headaches. Those with malignant anemia can experience a lack of hydrochloric acid in their gastrointestinal tract, which can lead to diarrhea, nausea and loss of application. Other symptoms that may develop include physical weakness with minimal exertion, liver enlargement, shortness of breath and bile of urine and fecal matter.
Tests used to confirm the diagnosis of malignant anemia may include complete blood count and in some cases bone marrow examination. Bone marrow examination, also known as a sternal roosterek, zahrnuje sběr tekutiny kostní dřeně získané s dutý jehlou vloženou do prsu nebo pánevní kosti. The Schilling test can also be administered in the phases to evaluate the body's ability to absorb vitamin B12 and control B12 levels.
Once the cause of the anemia and the scope of identified deficiency is determined, treatment usually includes the use of supplements to compensate for deficiency. If the anemia is caused by a deficiency of vitamin B12, monthly B12 injections may be administered and diet changes are recommended for restoring the right levels.
individuals whose anemia is caused by a lack of folate may undergo short -term injections of folic acid supplements until the condition is repaired. The supplement can also be administered orally in the short term. Individuals whose lack of folate is caused by improper absorption of folic acid may be necessary for lifelong use of the supplement.
complications associated with megaloblastic anEmia may include the development of gallbladder diseases, stomach polyps and stomach cancer. Individuals with megaloblastic anemia are exposed to an increased risk of developing neurological problems if the lack is not treated. Other complications may include infertility, congestive heart failure and permanent skin color.