What Is Peripheral T-Cell Lymphoma?
Peripheral T-cell lymphoma is a group of aggressive tumors with heterogeneous morphological changes with a mature T-cell immunophenotype. They account for 7% of all cases of Non-Hodgkin lymphoma (NHL). Many different clinical syndromes are included in this group of diseases.
- Western Medicine Name
- Peripheral T-cell lymphoma
- Main cause
- Immunodeficiency, environmental factors
- Contagious
- Non-contagious
| Cen Xinan | (Chief physician) | Department of Hematology, Peking University First Hospital |
- Peripheral T-cell lymphoma accounts for 7% of all non-Hodgkin lymphoma (NHL) cases. The diagnosis is mainly made by a professional hematologist based on the appropriate biopsy pathology and immunophenotype. First-line treatment options for peripheral T-cell lymphoma include CHOP, and young patients often consider hematopoietic stem cell transplantation early in the course of the disease. Peripheral T-cell lymphoma usually has a poor prognosis.
Introduction to peripheral T-cell lymphoma disease
- Peripheral T-cell lymphoma is a group of aggressive tumors with heterogeneous morphological changes with a mature T-cell immunophenotype. They account for 7% of all cases of Non-Hodgkin lymphoma (NHL). Many different clinical syndromes are included in this group of diseases.
Peripheral T-cell lymphoma diagnosis
- To diagnose peripheral T-cell lymphoma or its specific subtypes, a professional hepatologist must be based on the appropriate biopsy pathology and immunophenotype. Most peripheral T-cell lymphomas are CD4-positive, but rarely CD8-positive, CD4 and CD8 double-positive, or NK cell immunophenotype. No characteristic genetic abnormalities. However, translocations involving T cell antigen receptor genes on chromosome 7 or 14 can be detected. The differential diagnosis of suspected peripheral T-cell lymphoma includes reactive T-cell infiltration. In some cases, T cell receptor gene rearrangement studies have proven to be a monoclonal T cell population, which is helpful for diagnosis. [1]
Peripheral T-cell lymphoma treatment
- Alternative first-line treatment options include CHOP, EPOCH, and HyperCVAD / MTX-AraC. Hematopoietic stem cell transplantation is often considered early in the course of young patients.
Peripheral T-cell lymphoma prognosis
- Unfortunately, patients with peripheral T-cell lymphoma often exhibit poor prognostic factors, with> 80% of patients with IPI scores 2 and> 30% of patients with IPI scores 4. As predicted by IPI, peripheral T-cell lymphoma has a poor prognosis, with only 25% of patients surviving more than 5 years after diagnosis.