What Is Renal Osteodystrophy?

Renal osteodystrophy A bone metabolic disease caused by chronic renal failure. Referred to as renal osteopathy. Presented as calcium and phosphorus metabolism disorders, acid-base balance disorders, skeletal deformities and can cause secondary hyperparathyroidism. Bone manifestations include osteoporosis, osteomalacia, fibrocystic osteitis, osteosclerosis, and metastatic calcification. Infancy may cause growth and development disorders. The purpose of treatment is to relieve symptoms, prevent bone deformities and fractures, hyperphosphatemia and vitamin D deficiency; relieve hyperparathyroidism, prevent metastatic calcification of soft tissue, and strengthen bone mineralization. Patients with increased uremia undergo dialysis or kidney transplantation.

Renal osteodystrophy

Overview of renal osteodystrophy

Renal osteodystrophy A bone metabolic disease caused by chronic renal failure. Referred to as renal osteopathy. Presented as calcium and phosphorus metabolism disorders, acid-base balance disorders, skeletal deformities and can cause secondary hyperparathyroidism. Bone manifestations include osteoporosis, osteomalacia, fibrocystic osteitis, osteosclerosis, and metastatic calcification. Infancy may cause growth and development disorders. The purpose of treatment is to relieve symptoms, prevent bone deformities and fractures, hyperphosphatemia and vitamin D deficiency; relieve hyperparathyroidism, prevent metastatic calcification of soft tissues, and strengthen bone mineralization. Patients with increased uremia undergo dialysis or kidney transplantation.

Renal bone dystrophy disease symptoms

In children or adolescents, the disease manifests as stunted and weak muscles; duck gait during walking, knee valgus or varus; swelling of the metaphysis or rib cartilage junction, and femoral epiphysis slippage; severe cases can cause femur Neck fibrous osteitis. Adults show symptoms of osteomalacia and tenderness in the area of Looser degeneration.

Pathological changes of renal osteodystrophy

(1) There is an excessive amount of osteoid in bone tissue.

(2) Enlargement of parathyroid glands.

(3) Calcification of soft tissue.

(4) The kidney and urinary tract have primary pathological changes that cause renal failure.

Diagnosis and differentiation of renal osteodystrophy

It is not difficult to make a diagnosis based on comprehensive analysis of clinical symptoms, x-ray signs, and characteristics seen in laboratory tests.

Laboratory diagnosis of renal osteodystrophy

(1) Total serum calcium: those with symptoms of osteomalacia are generally low in total serum; those with fibroostitis are generally normal or high; those with severe renal failure, serum protein-bound calcium and ionized calcium Both are low.

(2) Inorganic phosphorus in serum: Generally, it is extremely high.

(3) Alkaline alkaline phosphatase, serum magnesium and blood urea are all increased; the carbonate in plasma is reduced due to acidosis, and proteinuria and hypouricemia are present.