What Is Seronegative Rheumatoid Arthritis?

Rheumatoid arthritis is a chronic systemic autoimmune disease that is predominantly associated with joint disease. The main clinical manifestations are joint swelling and pain caused by the synovium of the small joints, followed by cartilage destruction and narrowing of the joint space. In the later stage, joint stiffness, deformity and dysfunction are caused by severe bone destruction and absorption. In China, the prevalence of rheumatoid arthritis is 0.24-0.5%. There are more women than men, about 2-3: 1, and they can occur at any age, with the most being 20-50 years old. This disease is mostly a recurrent disease with a high disability rate and a poor prognosis. There is no good cure.