What Is Sideroblastic Anemia?

Hematopoietic anemia is a group of iron utilization disorders. It is characterized by the appearance of a large number of ring-shaped iron granulocytes in the bone marrow, ineffective production of red blood cells, excessive tissue iron reserves, and small cell hypochromic anemia in peripheral blood. Severe anemia can be transfused with red blood cells or whole blood as appropriate.

Iron granulocyte anemia

Hematopoietic anemia is a group of iron utilization disorders. It is characterized by the appearance of a large number of ring-shaped iron granulocytes in the bone marrow, ineffective production of red blood cells, excessive tissue iron reserves, and small cell hypochromic anemia in peripheral blood. Severe anemia can be transfused with red blood cells or whole blood as appropriate.

The disease is divided into acquired and hereditary, as well as vitamin B6 reactive anemia. Acquired is divided into primary and secondary. Poor use of iron, impaired heme synthesis, and ineffective production of red blood cells are the main links in the pathogenesis of this disease. Lack of various enzymes and coenzymes related to heme synthesis, reduced activity and blocked activity are the pathogenesis of this disease. Any reason that affects the activity of these enzymes can lead to poor utilization of iron and impaired heme synthesis, resulting in the formation of hypochromic anemia, a large amount of iron accumulates in red blood cells and various tissues, impairs the shape and function of red blood cells, and causes premature destruction of red blood cells Invalid build. Large amounts of iron are deposited in various tissues to form

1. Heritability is mostly adolescent, male and have family history; acquired sex often does not have family history. Primary, no cause, more than 50 years of age. Secondary is more common in patients with isoniazid, biazinamide, chloramphenicol, and anticancer drugs for too long. Can also be seen in tumors and myeloproliferative diseases.

2. Slow onset,

Diagnose based on

1. Slow onset with anemia as the main symptom.

2. May have hepatosplenomegaly.

3. Hematology showed hypopigmented anemia, showing erythrocytes, and reticulocytes were normal or slightly elevated. White blood cells and platelets are normal.

4. Bone marrow hyperplasia was significantly active, red blood cell morphology was different, and ring-shaped iron granules of red blood cells appeared> 15%. The granulocytes and megakaryocytes are normal.

5. Serum iron, ferritin saturation, plasma iron conversion rate and erythrocyte free proto-bulin increased, plasma iron binding capacity, and iron utilization decreased.

6. Decreased neutrophil alkaline phosphatase score.

Principles of iron granulocyte anemia treatment

1. Use vitamin B6 in large doses.

2. Use of androgens.

3. Appropriate use of adrenal corticosteroids.

4. Can use iron removal preparations to reduce the accumulation of excessive iron in the body.

5. Severe anemia can be transfused with red blood cells or whole blood as appropriate.

Principles of medication for iron granulocyte anemia

1. Oral vitamin B6, Stanozolol, and folic acid are the main oral and early cases.

2. In the middle stage, if the symptoms of anemia are severe, vitamin B6 and androgen can be injected, and the concentrated red blood cells or whole blood can be appropriately infused under the condition of adding iron removal agent.

3. Actively treat the primary disease.