What is sideoblastic anemia?
Sideoblastic anemia is a blood disorder in which red blood cells do not normally develop, leading to the formation of what is called annular sideoblasts in the bone marrow, along with the general symptoms of anemia such as fatigue and pale skin. A ring or ring, sideoblast is an immature red blood cell with an iron circle around the nucleus. Sideoblastic anemia is associated with a number of different diseases and can be inherited, so the person is born with the condition or can be obtained later in life. It can be part of myelodysplastic syndrome where blood cell production in bone marrow becomes abnormal with the risk of developing in leukemia or blood and bone marrow cancer. Drugs are a common cause of sideoblastic anemia, especially alcohol, as well as certain antibiotics, chemotherapy and heavy metals such as lead.
hemoglobin, a molecule that binds oxygen inside the red blood blood, and the heme parts that usually contain iron. For sideoblastic anemia immature red blood cells in the bone marrow cannot properly occupyT iron into the hemoglobin, resulting in the iron in the cell, which characterizes the ring around the nucleus. This is known as a sideoblastic ring and cells are referred to as a ring or ring, sideoblasts.
Most cases of sideoblastic anemia are obtained rather than inherited, with the most common cause of alcohol abuse. Other causes include drugs such as isoniazide used in the treatment of tuberculosis, shortcomings of copper and vitamin B6 and lead or zinc poisoning, as well as myelodysplastic syndromes and other bone marrow diseases. Inherited forms of the condition are more common in men and, in mild cases, can remain undetected up to an age of 40 or more.
sideoblastic anemia can be diagnosed when looking at the bone marrow under the microscope, where you can see annular sideroblasts. Some cells from general circulation will usually seem pale and afterThey suffer a typical red color associated with normal hemoglobin. In hereditary forms of anemia, cells may also be smaller than usual.
Inherited sideoblastic anemia can sometimes be treated with vitamin B6, with treatment withdrawn for life if the disease reacts. While some of the causes obtained by sideoblastic anemia can be reversed, such as some antibiotics replaced by others or alcohol stop consumption, it is not always possible. Vitamin B6 treatment can also work in some cases obtained by anemia and sometimes blood transfusion can be performed.