What is neuropathy with small fibers?

Small fiber neuropathy-known as peripheral neuropathy with small fibers, neuropathy C-fiber and sensory neuropathy with small fibers (SFSN)-is a type of peripheral neuropathy that affects small nerve fibers near the skin surface. Symptoms of the trade mark of this particular condition are special sensitivity to heat or colds, although other symptoms are often present consistent with general neuropathy. The patient suffering from this condition may be concerned about the prickly burning feeling that comes and goes without apparent cause. It can affect different parts of the body, but most often legs and legs. In addition to the neuropathy of small fibers, which as its name suggests, it affects the nerves of small fiber, can also be neuropathy with large fibers. Small fiber nerves generally perform only pain and temperature acerties from the skin surface, while for things like motor functions, large fiber nerves are responsible.

Although a large proportion of peripheral neuropathy cases are considered idiopathic - this nThe emotional, identifiable cause - neuropathy with small fibers has several main causes. However, the diagnosis is not always easy, because the condition is considered completely separated from the neuropathy of large fibers, which often affects a certain part of the nerves with small fibers.

The diagnosis of the doctor must therefore determine that only small fibers are affected, so that it is a small fiber neuropathy. This is usually done through the excretion process and first excludes all other possible causes. The most common final cause of proper neuropathy of small fibers, unless it is considered an idiopathic case, the condition is known as Fabry's disease. Other causes may include diabetes, human immunodeficiency virus (HIV) and neuralgia, although it is less common.

Fabry's disease is a rare genetic disorder that, if undiagnosed and untreated, may lead to damage, among other thingskidney, heart attacks and strokes. Small fiber neuropathy is one of the main early warning symptoms of the disease. The relationship between neuropathy and Fabry's disease is therefore important as a way of going to later serious results that may occur.

Since 2010, there has been no cure for neuropathy with small fibers, partly because it is often caused by Fabry's disease. When it is diagnosed as such, it is symptomatically treated with techniques such as intravenous immunoglobulin (IVIG) and plasmapheresis, which are therapies of alternative proteins in plasma. They are usually performed in conjunction with the treatment of Fabry's disease. When it is diagnosed as idiopathic, the replacing protein in plasma, along with various antidepressant and anti-epilemips of drugs, has been shown to be shown to reduce general neuropathic symptoms.