What Is the Connection Between Caffeine and Blood Sugar?

Compound propranolol caffeine tablets are used for typical and atypical migraine, can reduce and alleviate migraine attacks, and prevent migraine attacks.

Drug Name: Compound propranolol caffeine tablets

Drug type: prescription
Special medicine: Psychotropic substances, stimulants

Compound propranolol caffeine tablets ingredients

This product is a compound preparation, and its components are each containing 70mg of caffeine, 10mg of propranolol hydrochloride, and 100mg of phenytoin sodium.

Properties of Compound Propranolol Caffeine Tablets

This product is a sugar-coated tablet, except for the coating, it is off-white.

Indications of compound propranolol caffeine tablets

It is used for typical and atypical migraines, which can reduce and alleviate migraine attacks and prevent migraine attacks.

Compound propranolol caffeine tablets

oral. Adults 1 tablet at a time, 3 times a day. After the disease is basically controlled, the dose can be discontinued after the dose is reduced.

Adverse effects of compound propranolol caffeine tablets

Occasionally dizziness, nausea, palpitation, drowsiness, fatigue, difficulty falling asleep, allergic (rash) itching, no other adverse reactions were seen. According to literature data, the following adverse reactions can occur when taking caffeine, propranolol hydrochloride, and phenytoin sodium alone, which may also occur when taking this product.
1. Caffeine-containing drinks are occasionally taken too much, which can cause headaches or insomnia. Tensions, agitation, and anxiety can occur over a long period of time.
2. Propranolol hydrochloride can cause dizziness or dizziness (caused by hypotension) and slow heart rate (less than 50 times / minute). Rarely, bronchospasm and dyspnea, congestive heart failure, confusion (especially in older people), depression, and unresponsiveness.
3. The more common are phenytoin sodium that can cause behavior changes, awkwardness or unstable gait, confused thinking, persistent nystagmus, weakened muscles, articulation, hand tremor, swollen gums, bleeding, and hairy. Swelling of the lymph nodes in the neck or armpit, fever, or rash are rare.

Compound propranolol caffeine tablets taboo

The following patients should be disabled:
1. Patients with gastric ulcer;
2. Patients with bronchial asthma or history of bronchospasm;
3. Cardiogenic shock, - degree cardiac block, severe heart failure, acute heart failure, sinus bradycardia, metabolic acidosis (such as some diabetic patients), patients after long-term fasting ;
4. People with allergies to hydantoin drugs;
5. Asthma Syndrome.

Cautions of compound propranolol caffeine tablets

1. This product should be used with caution in the following cases: allergy history, congestive heart failure, diabetes, emphysema or non-allergic bronchitis, liver insufficiency, hypothyroidism, Raynaud's syndrome, renal failure, alcoholism, anemia Wait.
2. The blood concentration of phenytoin sodium should be monitored regularly during the application of this product.
3. During the application of this product, blood routine, blood pressure, heart function, EEG, thyroid function, liver function, kidney function should be checked regularly. People with diabetes should check blood glucose and lymph nodes, skin, mouth, etc. regularly.
4. Application of this product can produce gingival hyperplasia. It usually appears within 6 months after the start of treatment. Strengthening oral hygiene during medication can reduce the speed and extent of its occurrence.

Compound propranolol caffeine tablets for pregnant and lactating women

Banned for pregnant and lactating women.

Compound propranolol caffeine tablets for children

At present, the safety and effectiveness of children's medication have not been determined and should be disabled.

Compound propranolol caffeine tablets for elderly

The elderly have a low ability to metabolize and excrete this product, and should appropriately adjust the dose, and often monitor the blood concentration of phenytoin sodium.

Compound propranolol caffeine tablets drug interactions

1. Because this product can affect blood sugar levels, the dosage of the latter should be adjusted when it is used in combination with hypoglycemic agents.
2. When combined with corticosteroids, glucocorticoids and mineralocorticoids, oral contraceptives containing estrogen, adrenocorticotropic hormone, cyclosporin, digitalis, estrogen, levodopa or quinidine The efficacy of these drugs can be reduced.
3. Combined with anticoagulants such as coumarins or chloramphenicol, isoniazid, butazone, sulfa, can reduce the metabolism of this product and may increase the toxicity of this product.
4. Long-term application of paracetamol in patients can increase the risk of liver poisoning.
5. Forbidden to use with monoamine oxidase inhibitor, because it can cause extreme hypotension.

Compound propranolol caffeine tablets overdose

No such information is available. Once an overdose occurs, treatment can be carried out according to the general management principles of drug poisoning.

Pharmacology and toxicology of compound propranolol caffeine tablets

1. Pharmacological action This product is a compound preparation composed of caffeine, propranolol hydrochloride, and phenytoin sodium. Caffeine stimulates the cerebral cortex, increases the sensitivity to the outside world, and constricts cerebral blood vessels. Propranolol is a non-selective beta-adrenergic receptor blocker, which can slow heart rate, reduce cardiac contractility, and reduce vasodilator reactivity to beta-adrenergic receptor agonists. Phenytoin is an antiepileptic drug that promotes neuronal sodium efflux and stabilizes cell membranes, and counteracts excessive excitability caused by overstimulation or environmental factors that can change the sodium gradient of cell membranes, including post-synaptic tonicity enhancement. Reduction in post-synaptic enhancement can inhibit cortical lesions from spreading to adjacent cortical areas.
2. Toxicological study Propranolol was administered to rats in an admixture method (concentration of 0.05%), and no effect on fertility was observed. Rats and mice were orally given propranolol at a dose of up to 150 mg / kg / day for 18 months without any drug-related carcinogenesis.

Pharmacokinetics of Compound Propranolol Caffeine Tablets

According to reports in the literature, gastrointestinal absorption is more complete after oral propranolol hydrochloride, peak plasma concentration in 1-1.5 hours, extensive metabolism in the liver, a large number of liver metabolism inactivation before entering the systemic circulation, bioavailability It is 30% and the plasma protein binding rate is 93%. It can penetrate the blood-brain barrier and produce a central response. The half-life is 2-3 hours and is mainly excreted by the kidneys.
Phenytoin sodium is slowly absorbed orally, with a bioavailability of about 79%, and peak plasma concentrations 4-12 hours after oral administration. Stable in 7-10 days, with an average half-life of about 22 hours. It is mainly metabolized in the liver. Metabolites have no pharmacological activity and are excreted by the kidneys. After oral administration, caffeine is absorbed quickly from the gastrointestinal tract, but is irregular, with a half-life of about 3.5 hours. There is no accumulation in the body. Prototypes and degradation products are mainly excreted through the urine.

Storage of compound propranolol caffeine tablets

Shaded and sealed.

Packaging of propranolol caffeine tablets

Double aluminum package, 6 pieces / board.

Expiry date of compound propranolol caffeine tablets

Tentative 24 months ^[1]