What Is the Epidermal Growth Factor Receptor?

EGFR (epithelial growth factor receptor) itself has tyrosine kinase activity. Once combined with epidermal growth factor (EGF), it can activate related genes in the nucleus, thereby promoting cell division and proliferation. Gastric cancer, breast cancer, bladder cancer, and head and neck squamous cell carcinoma have increased expression of EGFR.

Epidermal growth factor receptor

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EGFR (epithelial growth factor receptor) itself has tyrosine kinase activity. Once combined with epidermal growth factor (EGF), it can activate related genes in the nucleus, thereby promoting cell division and proliferation. Gastric cancer, breast cancer, bladder cancer, and head and neck squamous cell carcinoma have increased expression of EGFR.

Epidermal cell growth factor receptor (EGFR) is a huge transmembrane glycoprotein, with a molecular weight of about 180 kDa, and has ligand-induced tyrosine protein kinase activity. It is a member of the conserved receptor family of ErbB. This Other members of the family include HER2 / Neu / ErbB2, HER3 / ErbB3 and HER4 / ErbB4. The common characteristics of ErbB receptor are: it contains an extracellular (EC) ligand binding region, is a single transmembrane region composed of two repeated cysteine-rich regions, and contains tyrosine protein kinase and itself The intracellular sequence of the phosphorylation site. When bound to a ligand, the receptor dimerizes, which is essential for changing the high affinity state between the ligand and the receptor and for the receptor to transmit phosphorylation signals between molecules. The formation of homodimers or heterodimers depends on the relative levels of the four receptors and the activated ligands.