What is Parkinson's pathophysiology?

pathophysiology concerns changes in normal biochemical, mechanical and physical processes of the body. Pathophysiology of Parkinson's disease concerns physical and biochemical changes in the brain, which in turn produce visible abnormal mechanical and physical functioning in the rest of the body. An example of this is the characteristic tremors associated with Parkinson's disease. Although affecting and contributing factors may vary between early onset, juvenile and standard Parkinson's disease, Parkinson's pathophysiology is mostly the same. Putamen and core . These structures are partly responsible for controlling voluntary movement. Next to the basal ganglia lies nigra nigra , the brain area containing nerve cells that produce chemical dopamine. Dopamine is a neurotransmitter that transmits messages or signals between nerve cells.

Corpus striatum are gray and white tissue strips that lie in the core of Caudate and Putamen and are associated with nigra nouns. Dopamine productionThe nigra substantium is transmitted along the connecting tissue and is released into Corpus striatum . This process is essential for smooth, controlled, coordinated and voluntary muscle movement.

Parkinson's disease is damage to dopamine production, resulting in a reduction and ineffective neurotransmis or transmission of messages between brain cells. It causes nerve cells to shoot irregularly and inappropriately, resulting in an uncontrolled, involuntary movement and muscle rigidity. Parkinson's pathophysiology begins with death or disruption from cells producing dopamines in Nigra.

Parkinson's pathophysiology is also characterized by the presence of Lewy's bodies in the brain, specifically in Nigra nouns. Lewy bodies are abnormal protein structures found in the brain. They are a characteristic feature of Parkinson's disease and contain amino acid protein a-Synulein . In a normal stateAt normal levels, the function of this protein is to regulate the activity of dopamine transporters. At abnormal levels or in a mutated state, for example in Lewy's bodies, it will contribute to cellular death and dysfunction.

both Lewy's bodies and a-Synulein are important for Parkinson's pathophysiology when it occurs in people under 40 years of age and in hereditary cases. Two mutations of A-Synuclein and were identified in the early initial hereditary cases of Parkinson. In the case of Parkinson, with the advent of symptoms, the last age of 60 years includes the pathophysiology of the cellular death related to the area. It is estimated that 13 percent of neurons producing dopamines die over every decade of life. This means that more cases of Parkinson's cases will happen because people live longer because up to 80 years of age could be lost from 80 percent to 90 percent of their dopamine cells. Not everyone loses so many cells or develops Parkinson.