How Was Aspirin Invented?
Aspirin (acetylsalicylic acid) is a white crystalline or crystalline powder, odorless or slightly odorous with acetic acid, slightly soluble in water, easily soluble in ethanol, soluble in ether and chloroform, and the aqueous solution is acidic. This product is a derivative of salicylic acid. After nearly 100 years of clinical application, it has proven to be effective in alleviating mild or moderate pain, such as toothache, headache, neuralgia, muscle soreness and dysmenorrhea. It is also used for colds, flu, etc. Antipyretic fever, rheumatic pain, etc. In recent years, aspirin has been found to inhibit platelet aggregation and prevent thrombosis. It is clinically used to prevent transient ischemic attacks, myocardial infarction, artificial heart valves and venous fistulas or other postoperative thrombosis. [1]
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- Aspirin (acetylsalicylic acid) is a white crystalline or crystalline powder, odorless or slightly odorous with acetic acid, slightly soluble in water, easily soluble in ethanol, soluble in ether and chloroform, and the aqueous solution is acidic. This product is a derivative of salicylic acid. After nearly 100 years of clinical application, it has proven to be effective in alleviating mild or moderate pain, such as toothache, headache, neuralgia, muscle soreness and dysmenorrhea. It is also used for colds, flu, etc. Antipyretic fever, rheumatic pain, etc. In recent years, aspirin has been found to inhibit platelet aggregation and prevent thrombosis. It is clinically used to prevent transient ischemic attacks, myocardial infarction, artificial heart valves and venous fistulas or other postoperative thrombosis. [1]
- Properties: white needle-like or plate-like crystal or crystalline powder. Odorless, slightly sour.
- The molecular formula is: C9H8O4
The molecular structure is: CH3COOC6H4COOH
Molecular relative mass: 180.16
- CAS number: 50-78-2
- As early as 1853, Charles, Gerhardt was synthesized by salicylic acid and acetic anhydride.
- Inhibition of aspirin on platelet aggregation, aspirin enteric-coated tablets are as follows:
- Reduce risk of suspected patients with acute myocardial infarction
- Prevent recurrence of myocardial infarction
- Secondary prevention of stroke
- Reduce the risk of transient ischemic attack (TIA) and its secondary stroke
- Reduces risk of angina pectoris in patients with stable and unstable angina
- Arterial surgery or intervention
- Aspirin is a long history antipyretic and analgesic. Aspirin is widely used in clinical treatment of fever, headache, neuralgia, muscle pain, rheumatic fever, acute rheumatoid arthritis, etc. due to its easy absorption after oral administration, wide distribution in tissues throughout the body, and strong effect. With the widespread use of aspirin, its adverse reactions have gradually increased. Therefore, when aspirin is used to treat various diseases, its adverse reactions should be closely monitored.
- Aspirin salicylic acid
- Compound aspirin is a compound antipyretic and analgesic, and both aspirin and phenacetin have antipyretic and analgesic effects. Aspirin can inhibit
- Children under 12 may cause
- Aspirin is widely used, but many people do not know enough about its toxic and side effects, and some problems often occur. Here are the precautions for applying aspirin to achieve the purpose of promoting strengths and avoiding weaknesses.
- First, one week before surgery should be stopped to avoid
- Aspirin has many wonderful uses in flower and tree cultivation, because aspirin can be decomposed into salicylic acid and acetic acid in water. Salicylic acid has antibacterial, anti-inflammatory and antiseptic effects. Acetic acid can inhibit the biological activity of glycolate oxidase and improve photosynthesis of flowers and trees. Effect to increase photosynthetic products. Used in flower and tree cultivation can not only improve the survival rate, but also promote robust growth, improve stress resistance, increase the survival rate of tree stumps, and extend the life of flower arrangements. The following describes the specific operation method:
- Improve stress resistance
- Spraying the stems, branches and leaves of flowers and plants with a 500 mg / kg aspirin solution can reduce water transpiration in the plant and improve the ability of the flowers and plants to withstand the arid environment. Combined with watering, watering or spraying aspirin (1 kg of water to dissolve 1 tablet), it can promote the closure of leaf stomata, reduce the transpiration and loss of leaf moisture, reduce high temperature burns, and improve the drought and cold resistance of flowers and trees.
- Increase survival rate
- Treating stump bonsai with aspirin can make the stump germinate in advance and improve
- Aspirin revised in 2010 Chinese Pharmacopoeia
- Page number: Chinese Pharmacopoeia 2005 Edition -283
- [Revision]
- Free salicylic acid was determined by high performance liquid chromatography (Appendix VD).
- Chromatographic conditions and system suitability tests use octadecylsilane bonded silica as a filler; acetonitrile-tetrahydrofuran-glacial acetic acid-water (20: 5: 5: 70) as the mobile phase; detection wavelength is 303nm. The number of theoretical plates calculated from the salicylic acid peak is not less than 5000, and the resolution of the main aspirin peak and the salicylic acid peak should meet the requirements.
- Preparation of test product solution Take about 100mg of this product, weigh it accurately, place it in a 10ml measuring bottle, add an appropriate amount of 1% glacial acetic acid in methanol solution, shake to dissolve, and dilute to the mark, shake well, just before use New)).
- Preparation of reference solution: Take about 10mg of salicylic acid reference solution, weigh it accurately, place it in a 100ml measuring bottle, add an appropriate amount of 1% glacial acetic acid in methanol to dissolve it, dilute it to the mark, and shake it; In the bottle, dilute to the mark with 1% glacial acetic acid in methanol and shake to obtain.
- The measurement method immediately accurately measured 10 l of each of the test solution and the reference solution, injected them into the liquid chromatograph, and recorded the chromatogram. If the salicylic acid chromatographic peak is displayed in the chromatogram of the test product, the salicylic acid content in the test product shall be calculated by the peak area according to the external standard method. The salicylic acid shall not exceed 0.1%.
- [Updated]
- Relevant substances were determined according to high performance liquid chromatography (Appendix VD).
- Chromatographic conditions and system applicability tests use octadecylsilane bonded silica as a filler, acetonitrile-tetrahydrofuran-glacial acetic acid-water (20: 5: 5: 70) as mobile phase A, and acetonitrile as mobile phase B. Press The following table performs linear gradient elution; the detection wavelength is 276 nm. The retention time of the aspirin peak is about 8 minutes. The theoretical number of plates based on the aspirin peak is not less than 5000. The resolution of the aspirin peak and the salicylic acid peak should meet the requirements.
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- Take about 0.1g of the product by measurement to obtain the test solution; accurately measure 1ml of the test solution, place it in a 200ml measuring bottle, dilute to the mark with 1% glacial acetic acid in methanol, and shake to obtain the control solution; 10 ml of the control solution was accurately measured, placed in a 100 ml measuring flask, diluted to the mark with a 1% glacial acetic acid methanol solution, and shaken to obtain a sensitivity test solution. 10 l of each of the test solution, the control solution, the sensitivity test solution, and the salicylic acid reference solution under the salicylic acid test were accurately measured, injected into a liquid chromatograph, and the chromatogram was recorded. If impurity peaks appear in the chromatogram of the test solution, except for the single impurity peak, solvent peak, and salicylic acid peak, which are smaller than the aspirin main peak area in the sensitivity test solution, the sum of the areas of the other impurity peaks must not be greater than the main peak area of the control solution. (0.5%).
- Take this product after losing weight, and put it in a phosphorus pentoxide dryer to dry under reduced pressure to constant weight. [98]