What are fibrates?
Fibrates are a class of medicines called hypolipidemic agents, as their main use is to reduce the level of triglycerides in the blood. In addition, they can slightly reduce the levels of "bad" cholesterol known as lipoprotein with low density (LDL). These drugs are used to treat people with high cholesterol and some other metabolic disorders. There are several varieties of fibrates, including Bezafibrates, Ciprofibrates and Gemfibrazil, which are available under brand names such as Bezalip®, Modalim® and Lopid®.
When prescribing for high cholesterol, fibrates are often prescribed with a different type of drug -reducing drug -called statin. This is because both types of drugs tend to reduce cholesterol in the blood only by a small amount. The use of fibrate and statin together improves the effect of cholesterol decreasing, because each type of drug works in a different way to reduce cholesterol levels. Generally doctors prescribe this combination of drugs of people with very high levels of triglycerides whoThey do not respond positively to dietary changes, in people with diabetes 2. Type and high triglycerides and for people with hereditary high cholesterol.
overall, fibrates are less effective than statins in reducing cholesterol blood. Yet fiber drugs are sometimes prescribed as monotherapy, which simply means that the drug is prescribed as the only drug reducing cholesterol. Monotherapy with fibrate drug is indicated when a person cannot tolerate side effects of statins. However, when used separately, fiber therapy is still effective treatment. This is because, in addition to lowering triglycerides and LDL cholesterol, these drugs can increase the level of so -called "good" cholesterol with high density (HDL) and can even improve insulin resistance symptoms.
Fibrate drugs work to improve lipid profiles in several ways. LDL cholesterol levels are reached because these drugs reduce the speed at whichLipoproteins with low density are produced in the liver. In addition, fiber drugs increase the speed at which these lipoproteins are removed from the blood.
The common side effects of fibrate include headaches, skin rashes, nausea and gastrointestinal problems. In most cases, these side effects are mild and temporary. Unusual side effects include fever, chest pain, reduced libido, difficulty breathing, dizziness, irregular heart rhythm and swollen legs or legs. Very rarely, pain and pain or slight liver damage could occur. Any and all side effects should be reported by doctors to ensure that symptoms are not the result of a serious reaction to medicines.
people who take fibrate and statin have a slightly increased risk of damage to the liver or muscles that can be monitored by regular blood tests. People with liver disease, kidney -seamen disease or gall bladder disease cannot tolerate fiber drugs. In addition, these medicines should notuse women who are pregnant or breastfeeding because there is a risk of harmful effects on the fetus or nursing child.