What Are Neuraminidase Inhibitors?

Neuraminidase is an enzyme composed of proteins on the surface of influenza virus particles and is the most critical enzyme for virus replication and spread. Viral neuraminidase inhibitor (Nueraminidase inhibitor) is a new type of flu control drug following amantadine and influenza vaccine. It can selectively inhibit the activity of neuraminidase on the surface of respiratory virus and prevent the offspring virus. The replication and release of particles in human cells effectively prevents colds and relieves symptoms. Application within 48 hours of the initial cold can significantly reduce the duration of the flu. ^[1]

Neuraminidase inhibitor

Right!

Neuraminidase is

Since the crystal structure of the influenza virus NA and its co-crystal structure with the natural substrate sialic acid were determined in 1983, research on influenza virus NA inhibitors, especially its sialic acid analogs, has made breakthrough progress. Knowledge of the crystal structure allows one to conduct molecular simulation studies to design and develop efficient and selective inhibitors.

Osmivir is an ethyl ester prodrug of GS4071. Its lipophilic 3-pentyloxy side chain has a strong affinity with the hydrophobic pocket of the active site of influenza virus NA, which blocks influenza virus NA from infecting cells The cleavage of sialic acid residues on the surface, which inhibits the release of virus particles from infected cells, is a highly selective influenza virus NA inhibitor.

Influenza virus NA plays an important role in the pathogenicity of influenza virus infection. Studies have confirmed that influenza virus NA inhibitors will dominate in future anti-flu treatments. Zanamivir and osimivir have significant antiviral activity. Both clinical and laboratory observations have shown that they have the ability to reduce influenza virus infection, and have curative effects on influenza A and B, with few adverse reactions.
(Guo Li, Wang Yuxia, garnet)