What Are Osmotic Diuretics?
"Osmotic diuresis" Osmotic diuresis refers to a diuretic phenomenon that occurs due to an increase in the concentration of solutes in the renal tubules and tubules in the collecting tube, which reduces water reabsorption. The increased solute content in the tubule fluid increased the osmotic pressure. Reabsorption of water decreases and urine volume increases.
Osmotic diuresis
- Chinese name
- Osmotic diuresis
- Foreign name
- osmotic diuresis
- Cause
- Polyuria is caused by osmotic diuresis
- Types of
- High osmotic pressure
- "Osmotic diuresis" Osmotic diuresis refers to a diuretic phenomenon that occurs due to an increase in the concentration of solutes in the renal tubules and tubules in the collecting tube, which reduces water reabsorption. The increased solute content in the tubule fluid increased the osmotic pressure. Reabsorption of water decreases and urine volume increases.
- Osmotic diuresis: When some solutes in the renal tubule fluid are not reabsorbed and remain in the renal tubules, the solute concentration in the renal tubule fluid can be increased. Due to the osmotic effect, part of the water is also retained in the tubules. As a result, the Na + in the renal tubule fluid is diluted and the concentration is reduced. As a result, the concentration gradient of Na + in renal tubules and epithelial cells decreases, so that the reabsorption of Na + is reduced and there is more Na + in the tubule fluid. In addition, more water is retained in the renal tubules, resulting in reduced water reabsorption and increased urine output and Nacl excretion.
- In short: osmotic diuresis is due to the formation of high osmotic pressure in plasma, glomerular filtrate and renal tubule fluid, preventing the reabsorption of raw urine by renal tubules and increasing urine output.
- Due to the increase in the concentration of solutes in the tubule fluid and the increase in osmotic pressure, the reabsorption of water by the renal tubules is hindered, and the phenomenon of increasing urine output is called osmotic diuresis.
- Polyuria in diabetic patients is caused by osmotic diuresis.
- For example, mannitol and sorbitol are used in clinical medicine because the renal tubules cannot reabsorb mannitol, thereby increasing the solute concentration of renal tubule fluid and increasing the osmotic pressure of the tubules. The principle of osmotic diuresis is used to achieve diuretic swelling purpose.