What Are the Alternatives to Estrogen Replacement Therapy?

It has been described in related entries that physical and psychological changes in postmenopausal women are related to estrogen deficiency. In 1932 Geist and Spielman first used estrogen preparations to prevent menopausal syndrome. But first realized that supplementing estrogen to postmenopausal women can not only treat various symptoms caused by menopause, but also delay and prevent the occurrence of menopausal related diseases. Rober Wilson in 1963, this method is called estrogen replacement therapy ERT). Since progestin is required in most cases, it is also referred to as hormone replacement therapy (HRT). Clinical practice and research for more than 30 years prove that

Estrogen replacement therapy

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It has been described in related entries that physical and psychological changes in postmenopausal women are related to estrogen deficiency. In 1932 Geist and Spielman first used estrogen preparations to prevent menopausal syndrome. But first realized that supplementing estrogen to postmenopausal women can not only treat various symptoms caused by menopause, but also delay and prevent the occurrence of menopausal related diseases. Rober Wilson in 1963, this method is called estrogen replacement therapy ERT). Since progestin is required in most cases, it is also referred to as hormone replacement therapy (HRT). Clinical practice and research for more than 30 years prove that

Estrogen replacement therapy

Its main benefits are:

(1) Adjust the disordered menstrual cycle during menopause transition;

(2) Reduce or eradicate various symptoms caused by low estrogen, such as hot flashes, sweating, etc., reduce urogenital atrophy, strengthen local resistance, reduce the probability of infection, and improve quality of life.

(3) Reduce excessive bone loss caused by low estrogen levels in the short and long term after menopause, and prevent or delay the occurrence of osteoporosis. It has been reported that for more than 6 years, the incidence of wrist or hip fractures can be reduced by more than 50%, and the incidence of vertebral fractures reduced by 90%. Women who take estrogen have better maternal coordination and are not prone to fall, which is one of the reasons for the reduction in fractures. Progestins also play a beneficial role in maintaining bone mass.

(4) Improve the composition of plasma lipoproteins, increase blood high-density lipoprotein cholesterol (HDL-C) concentration, and reduce total blood cholesterol and low-density lipoprotein cholesterol (LDL-C) levels. Studies have shown that: HDL-C increased by 10mg / L, the risk of cardiovascular disease was reduced by 3% to 5%, LDL-C decreased by 10mg / L, and the risk of cardiovascular disease was reduced by 2%.

Acts on blood vessel walls and protects vascular endothelial cells. Studies have shown that it can inhibit the formation of arterial wall atherosclerotic plaques, or reduce the volume of atherosclerotic plaques.

Regulates the formation of vasoactive substances, inhibits the contraction and proliferation of vascular smooth muscle, thereby dilates blood vessels, and improves myocardial blood supply and function.

A large number of epidemiological studies have shown that the risk of ischemic heart disease in postmenopausal women replaced with natural estrogen is reduced by 35% to 45%. The risk of myocardial infarction is reduced by 50%. The risk of death from cardiovascular disease is 40% to 50% of women who have not used HRT, and women who have coronary heart disease have greater benefits from HRT. Whether HRT can prevent stroke is uncertain.

Whether progestin has an adverse effect on the cardiovascular system is inconclusive.

(5) It has been reported in recent years that estrogen supplementation can improve the cognitive function of postmenopausal women and reduce or delay the occurrence of senile dementia. Improve sleep and brain function, improve mood, adjust psychology, strengthen physical strength, improve quality of life and work efficiency.

(6) Increasing the thickness of the skin (mainly the dermis) and blood supply are good for beauty.