What are different phenytoin interactions?
phenytoin is a common anticonvulsive medicine used to control seizure disorders. Drugs are structurally similar to the main transkvilizers, which may be responsible for its commonly stated side effects of drowsiness and sedation. While phenytoin works primarily on the brain-it reduces the excitability of an area that controls the motor function-more effects in long-term use show a wide range of effects on many body systems. To the complexity of understanding this drug is the fact that phenytoin is strongly bound to serum protein, but only a fraction that is "free" or unrestrained is pharmacologically active. Phenytoin interactions can occur anywhere in the huge sphere of drug influence and include interactions with almost 1,000 other medicines, food and other diseases.
The most commonly reported interactions of phenytoin are interactions with other medicines. Almost 1,000 drugs reportedly documented interactions with this anticonvulsant, including both over -the -counter and prescription. Some common free -the -counter medicines that interaction withWith this drug they include aspirin-kirters may increase the drug level in the body-A antacids that may have the opposite effect. Common prescription drugs with phenytoin interactions include diazepam, Lexapro® and furosemide.
phenytoin interactions can be caused by interference with absorption, contradictory effects, additive effects or even interruption of serum protein levels. Achieving the therapeutic dose of phenytoin is a truly leveling act that requires a re -evaluation whenever the drug is added or removed from the usual patient regime. Recommendations for patients with active seizures include testing laboratory blood work for both overall levels of phenytoin and free phenytoin levels before adding a new drug. Subsequent testing also recommends until the therapeutic levels of the phenytoin are stabilized. The same approximate procedure is recommended when a long -term medicine is removed from the drugpatient regime.
Foods are also indicated in some phenytoin interactions. Enteral feeding administered simultaneously with phenytoin dosing can reduce the drug level in the system. Spicy foods that guarantee over -the -counter antacides can also reduce the level of phenytoin. Alcohol intake also has a significant interaction of phenytoin, causing increased or reduced levels depending on whether alcohol intake is acute or chronic.
phenytoin interactions with other medicines, food or compounds can be significantly increased by accompanying diseases. The administration of anticonvulsants was associated with the advent of depression with suicidal tendencies or exacerbation of already existing depression. Patients suffering from diabetes mellitus can experience higher blood glucose levels with phenytoin administration. Phenytoin interference with vitamin D processing can cause conditions or injuries related to reduced skeleton density.