What factors affect the sufficient dose of cetirizine?

Second generation antihistamine drugs Zyrtec® and Reactine® use drugs of drug hydrochloride to treat symptoms of seasonal and chronic allergies. Occasionally they are also used in the treatment of chronic idiopathic skin irritation by reducing the occurrence, duration and severity of itching and hives. Unlike the first generation antihistamines, such as dipenhydramine, sedative and soporical side effects of cetirizine are significantly reduced in cetirizine. Higher doses of this drug can still exceed the blood barrier in sufficient level, but to cause drowsiness, so it is useful to determine what the lowest effective dose of cetirizine for the patient can be. Factors that may ensure the necessary dosage adjustment include patient age, liver health and the level of kidney function and several drug interactions.

in the treatment of symptoms of seasonal or chronic allergies, a typical initial dose used in a healthy adult isThe only daily dose of cetirizin 5 to 10 mg. Children over six years of age can be adult doses, while children aged two and five years should receive 2.5 mg initially up to a maximum of 5 mg daily per or two divided doses. Patients at the age of six months to two years should receive 2.5 mg of cetirizine doses only once a day, although patients one year or older may have their frequency of cetirizine doses twice a day. The recommended treatment regimen for chronic or recurring skin irritation is the same as for the treatment of allergies in adults and pediatric populations.

Because cetirizine is metabolised in the liver and removed from the bloodstream in the kidneys, patients with reduced renal or hepatic function may require lower dose of cetirizine than in typical adults. Children under six years of age with reduced kidfunction y or liver should not be administered by cetirizine at any level of dosage due to lack of research in its safety in this population. In the patientNTs with moderate to severe renal dysfunction or CRCL levels less than 30 ml/min should not be given more than 5 mg of cetirizin every day, and patients on dialysis should not after the same instructions. The same cetirizine dose recommendations relate to adult patients with reduced liver function.

Although generally considered a safe medicine, extreme drowsiness is one of the risks of cetirizine. Although the psychological side effects of cetirizine are not as serious as those that produced the antihistamines of the first generation, they still pose a significant risk under certain circumstances. For this reason, patients under the influence of cetirizine should refrain from operating motor vehicles or heavy machines.