What factors affect a sufficient dose of pramipexol?
Pramipexol, often sold under the Mirapex® brand, is a drug used to treat restless legs and many symptoms of Parkinson's disease and a number outside the brand. If the prolonged form of releasing the drug is used with food, even when the patient suffers from reduced liver function. The main factors affecting the appropriate dose of pramipexol are reduced kidney function and various recommendations for each drug forms.
In patients with reduced kidney function, but with creatinine (CRCL) levels higher than 60 ml/min can be used a standard dose of spring. If CRCL levels are between 35 and 59 ml/min, a standard dose of 0.125 mg should be used twice a day, although not more than 3.0 mg should not be taken daily. If CRCL levels are between 15 and 34 ml/min, the standard dose should only be administered once a day and raised to more than 1.5 mg daily. There is no acclaimed safe pramipexol in patients with CRCL levels less than 15 ml/min.
In patients suffering from reduced kidney function, with CRCL levels greater than 50 ml/min, no dosage adjustments are required when using the extended release form. However, patients with CRCL levels between 30 and 50 ml/min should only take the standard dose every other day. The dose should be increased carefully. Patients with CRCL levels less than 30 m/min should not take pramipexol, nor do patients have a history of sleep disorders, apnea or mental disorders.
When serving pramipexol in the form of immediate release, it is recommended to take an initial oral dose of 0.125 mg three times a day. Maintenance doses can be used to control symptoms up to a maximum daily dose of 4.5 mg pramipexol, with an increase in the daily dose every five to seven days as needed. In its prolonged form of release, 0.375 mg should be used once a day. The dose may be raised every five to seven days as needed, initially to 0.75 mg and then in 0.75 mg of increment up to a maximum dose of 4.5 mg daily.
Because pramipexol can produce side effects that resemble narcolepsy or some of the perceptual disorders associated with schizophrenia, patients who are at risk of these conditions should be prescribed alternative drugs to treat their conditions. However, they only occur in a small number of patients using drugs. The most common side effects of the pramipexol are dizziness, dry mouth, constipation and headaches.