What factors affect the sufficient dose of topiramate?
A number of factors affect the topiramate dose, including the condition it is used, whether used alone or in combination with other antiepileptic drugs and tolerance and patient response. Topiramate can be used to treat epilepsy and as prophylaxis of migraines and is usually available only according to the prescription. According to the manufacturer, it can be known under different trade names in different countries. The first is that it blocks sodium, a chemical connected to electrical pulses in the brain, which can cause seizures. Secondly, it increases the effect of GABA, a neurotransmitter that has a calming effect, and a third time, blocks glutamate receptors. Glutamate is another neurotransmitter that causes the excitement of nerve cells in the brain. The mechanism that works on the prevention of migraine attacks is not known. Initially, the dose of topiramate can be taken once a day, at night, butIt will be used twice a day as soon as the maintenance dose is established. When used in combination with other antiepileptic drugs as complementary therapy, the dose may be lower.
In children, there is also a sufficient dose of topiramate of the baby's weight and will also be performed until the maintenance dose. In older patients and patients with liver or kidney dysfunction, topiramate doses may be recommended. If you start topiramate, it should be done under the supervision of a doctor and slowly download to minimize the chance of downloading.
When using a drug for prophylaxis of migraine, it is a prevention of migraine attacks, the topiramate dose is usually 100 mg used as 50 mg twice daily. The drug will be started again at a low dose and increases every week with the attending physician who monitors the reaction and tolerance. The lowest effective dose will be prescribed.
as with any medicine, bEZ regardless of the dose of topiramate used can be contraindicated in patients with some basic clinical conditions and may interact with other drugs, including complementary, over -the -counter and homeopathic drugs. All should be discussed with a physician before starting treatment with topiramate, as if they had pregnancy, pregnancy and lactation.