What factors affect ZOCOR dosing?
Synthetic remedy based on organic compounds produced as a fermentation by -product of fungi, Zocor® is a member of the drug class known as statins. Like other statins, Zocor®, also known as Simvastatin, is used to treat increased blood cholesterol levels along with diet and exercise. Patients with a decent Chinese or who have a DNA variant known as one nucleotide polymorphism can be exposed to an increased risk of myopathy - a potentially serious side effect for Zocor® - especially if the drug is used in combination with therapeutic Niacin levels. It is essential that ZOCOR® dose is adjusted according to the condition to be treated, the patient's age, the level of kidney function, and the concomitant use of the drugs with which it interacts.
When administering drugs to reduce the risk of cardiovascular incident or to treat elevated blood lipid levels in adults, initial dosing ZOCOR® 10 to 20 mg should be administered orally once a day after evening meals. The evening can be the oneThe maintenance dose is given between 5 and 40 mg. The initial dose of ZOCOR® 40 mg is recommended in patients with a history of cerebrovascular disease such as cerebral incident, peripheral vascular disease, cardiovascular events or diabetes.
Adolescent patients with heterozygous familial hypercholesterolemia may begin preventive use of statins annually after puberty. The initial dose of ZOCOR® 10 mg oral should be administered once a day. The maintenance dose between 10 and 40 mg, with an increase in the dosage may also be evaluated at monthly intervals. Adults with homozygous familial hyperchoesterolemia should receive a dose of 40 mg once a day as a supplement to other therapies decreasing lipids.
Standard dose modifications must be made in patients suffering from slight tshes of O-Severe function in the kidney function. Patients with the level of clearance creatinine less than 25 milliliters per minute wouldThey should have the initial dosage ZOCOR® no greater than 5 mg once a day. Near monitoring should be accompanied by any increase in dose.
Similarly, the accompanying use of ranolazine or amlodipine requires daily maximum zocor® 20 mg. Patients using verapamil, diltiaz or amiodarone should not be administered no more than 10 mg zocor® daily. ZOCOR® can also respond with niacin supplementary when a daily dose of niacin exceeds 1,000 mg. The use of combined drug regimes is significantly higher than monotherapy and should be carefully considered.