What is a positive inotrop?
Inotrophe is a drug that increases or reduces muscle contraction. There are two main types of inotrops that are described as positive and negative. Positive inotrop increases muscle contraction, while negative inotrops reduce it. Usually positive inotrops are used to treat heart conditions in which the heart does not affix blood around the body effectively. Positive inotrop affects the heart by binding to what is called beta1 receptors on the heart muscle.
There are many inotrops, positive and negative. Positive inotrop known as Dobtamine is most commonly used to treat heart failure. Adrenaline, other positive inotrop, is used in extraordinary events such as a severe allergic reaction. Sometimes it is used in the treatment of heart attacks when the heart ceases to beat and during cardiopulmonary resuscitation, when the patient's breathing and heart rhythm stopped. Negative inotrops include drugs such as beta blockers that are used to use high blood pressure and condition known as angina in which mA heart muscle insufficient blood supply.
The side effects of inotrops are the result of their stimulation of other receptors, except for those that provide useful effects of the drug. In the sympathetic nervous system, there are three main types of receptors that are known as alpha receptors, beta1 and beta2 receptors. Dobutamine can cause blood vessels to be dilated due to its effect on beta2 receptors. When beta2 receptors are stimulated, it leads to muscle relaxation in the walls of respiratory passages and blood vessels. In the case of adrenaline, high doses of blood vessels cause due to the effect of the drug on alpha receptors.
When used to treat heart failure, positive inotrop is usually given as an infusion into the main vein. If the medicine is administered into a smaller vein on the limb, Re is the possibility that the blood vessels could be narrowed, thereby reducing the supply of blood to the tissue area. Starting with a low dose to a given amount gradually increasedIt is until the drug manifests itself. The fact that the heart works hard more leads to higher demand for oxygen and patients are monitored to ensure that they have the corresponding oxygen level in the blood. Demand for oxygen can be reduced by removing stressful factors such as pain, and environmental arrangement, so that the patient becomes as little as possible.