What is depression resistant to treatment?

Depression resistant to treatment (TRD) is a term used to describe a case of a large depressive disorder that does not seem to respond to conventional depressive treatment. Clinical psychiatry created this term 1974, when electroconvulsive treatment was widely used to treat serious depressive disorders that seemed to be immune to cognitive-behavioral therapy (CBT) and early antidepressant drugs. With the introduction of more diverse antidepressants, this term has been changed to describe a large depressive disease that does not respond to at least two of the newer antidepressant drugs. TRD treatment includes some invasive procedures such as stimulation of nerve vagus and also adding other psychiatric drugs. Some experts also pointed to coexisting physical conditions such as chronic namobronchial allergies that could cause chronic depressive symptoms such as restlessness and upset.Omlity return of depressive symptoms. Some patients do not feel any initial relief from symptoms. Etiology of depression resistant to treatment is controversial, and some scientists think that this is because the patient is under a failed emotional stress that has not been thoroughly solved, while others think that most cases stem from drugs that are not adopted correctly, the existence of additional medical or psychiatric diseases. The disease, which was considered most commonly adigned as a TRD, is a bipolar disorder where simple treatment of drugs does not deal with the completeness of clinical symptoms.

The first line of defense in the treatment of TRD is often the addition of atypical antipsychotic drugs such as aripiprazole. Sedical properties of atypical antipsychotic drugs sometimes reduce agitation in chronically depressive patients. Depression that represents agitation will ever be laterI diagnosed as a bipolar disease, as this symptom may be a sign of mania. However, treatment with atypical antipsychotics is harmful to some patients because drugs may actually worsen depressive symptoms.

Stimulation drugs such as methylphenidate and amphetamines can also be used to expand antidepressant drugs and psychotherapy in depression resistant to treatment. Treatment is most effective in patients who do not have a high level of agitation or restlessness. In the absence of these symptoms, the stimulation of the central nervous system can help patients who have a significant lack of motivation and desire. However, some psychiatrists are reluctant to experiment with the therapy based on the stimulance because stimulating drugs have a high potential for abuse. Other moléky stabilizing from, such as lithium, are often tested in the case of TRD.