What Is an Amylase Inhibitor?

-amylase inhibitor is an inhibitor of -amylase. For example, hairm produced by Streptomyces YM-25 strain; paim produced by Streptomyces S. corchoruchii strain; and trestatin produced by S. dimorph ogenes strains are all -amylase inhibitors. -amylase showed strong inhibitory effect, but did not inhibit -amylase and -glucosidase.

alpha-amylase inhibitor

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-amylase inhibitor can inhibit

Take tretstatin as an example: it contains three components of -amylase inhibitor: A, B, and C.

Foreign -amylase inhibitor research started earlier, as early as the 1940s

It has been reported that two double-headed inhibitors (ie, a subtilisin / -amylase inhibitor) and a subtilisin inhibitor in ragi have been isolated and their properties have been determined. Bifunctional inhibitors combine a molecular protease (subtilisin and trypsin) with a molecular alpha-amylase. The primary, secondary, and tertiary structures of trypsin and -amylase inhibitors have been carefully studied. Their molecular weight is 13,800 Da, contains 122 amino acids, and is arranged in the same way in WAI-0.28 and WAI-0.53 ( in wheat. -Amylase synergistic inhibitor) 5 disulfide bonds [27].

According to Leiner et al., Alpha-amylase inhibitors in kidney beans have a higher titer than other beans [8], which is doubled because they contain several special types of inhibitors (heat-resistant and heat-resistant) [28]. Has attracted the attention of many researchers at home and abroad. Lajolo et al. [9] reported that black beans contain two synergistic inhibitors; some of the inhibitors in cabbage beans are a kind of glycoprotein (Yamaguchi, 1993) with the same peptide (Pick, 1978) or different peptides [ 8], can inhibit the activity of mammalian and insect amylase, but does not inhibit the activity of -amylase in plants [27], so it has a potential role in the field of plant insect resistance genetic engineering research.

Yan Zhe [4] et al. Explored the distribution of -amylase inhibitors in fruits of plants with different starch contents, compared the relationship between -amylase inhibitors and starch content in different plants, and obtained - Amylase inhibitor content The starch content in plants has a strong correlation, that is, the higher the starch content, the higher the alpha-amylase inhibitor contained in the fruit of the plant.